Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.07.011
Abstract: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases worldwide. Formation of amyloid plaques consisting of amyloid-β peptides (Aβ) is one of the hallmarks of AD. Several lines of evidence have shown a… read more here.
Keywords: aggregation; mechanism; amyloid peptides; structural studies ... See more keywords
Citrullination of Amyloid-β Peptides in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00474
Abstract: Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullination has been shown to colocalize with extracellular amyloid plaques in postmortem AD patient brains. Amyloid-β (Aβ) peptides which aggregate and… read more here.
Keywords: amyloid peptides; alzheimer disease; citrullination amyloid; citrullination ... See more keywords
Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03397-2
Abstract: Age-related macular degeneration (AMD) is a progressive retinal neurodegenerative disorder characterized by extracellular deposits known as drusen. A major constituent of drusen deposits are Alzheimer disease-associated amyloid β (Aβ) peptides. To understand the etiology of… read more here.
Keywords: aav; amyloid peptides; pathology; peptides overexpression ... See more keywords
Graphene quantum dots for detecting monomeric amyloid peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c6nr10017a
Abstract: Detection of the concentration of amyloid monomers is of great importance in the diagnosis of amyloidogenesis. Herein, we propose a method to detect the concentration of amyloid β (Aβ) peptide monomers by utilizing the fluorescence… read more here.
Keywords: graphene quantum; amyloid; amyloid peptides; dots detecting ... See more keywords
The machinery behind amyloid peptides
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.363.6428.703-k
Abstract: Structural Biology β-Amyloid peptides, which are derived from amyloid precursor protein (APP), form the plaques in the brain that are characteristic of Alzheimer's disease. Zhou et al. report a high-resolution structure of a transmembrane segment… read more here.
Keywords: machinery behind; amyloid peptides; science; behind amyloid ... See more keywords
Distinct Binding Dynamics, Sites and Interactions of Fullerene and Fullerenols with Amyloid-β Peptides Revealed by Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20082048
Abstract: The pathology Alzheimer’s disease (AD) is associated with the self-assembly of amyloid-β (Aβ) peptides into β-sheet enriched fibrillar aggregates. A promising treatment strategy is focused on the inhibition of amyloid fibrillization of Aβ peptide. Fullerene… read more here.
Keywords: c60 c60; binding dynamics; molecular dynamics; amyloid peptides ... See more keywords
Chiral Linked Systems as a Model for Understanding D-Amino Acids Influence on the Structure and Properties of Amyloid Peptides
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063060
Abstract: In this review, we provide an illustration of the idea discussed in the literature of using model compounds to study the effect of substitution of L- for D-amino acid residues in amyloid peptides. The need… read more here.
Keywords: chiral linked; systems model; amyloid peptides; amino acids ... See more keywords