Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202400064
Abstract: Microglia play a crucial role in synaptic elimination by engulfing dystrophic neurons via triggering receptors expressed on myeloid cells 2 (TREM2). They are also involved in the clearance of beta‐amyloid (Aβ) plaques in Alzheimer's disease… read more here.
Keywords: microglia gravitate; amyloid plaques; trem2; via trem2 ... See more keywords
Vortioxetine administration attenuates cognitive and synaptic deficits in 5×FAD mice
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05452-9
Abstract: Rationale and objective Vortioxetine has been reported to exhibit a variety of neurobiological functions and neuroprotective effects. In the present study, we aimed to investigate the effects of vortioxetine on cognitive performance in a transgenic… read more here.
Keywords: mice vortioxetine; amyloid plaques; mice; vortioxetine administration ... See more keywords
Seizure susceptibility in the APP/PS1 mouse model of Alzheimer’s disease and relationship with amyloid β plaques
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.09.026
Abstract: Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction. We used 4-9month-old mice of the APP/PS1 mouse model of Alzheimer's… read more here.
Keywords: epileptiform like; alzheimer disease; like discharges; amyloid plaques ... See more keywords
In Search of an Identity for Amyloid Plaques
Sign Up to like & getrecommendations! Published in 2018 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2018.06.002
Abstract: In 1984, biochemists George Glenner and Caine Wong, in search of 'a unique amyloid fibril precursor protein in the serum' of Alzheimer disease (AD) patients, successfully isolated and sequenced the first 24 amino acids of… read more here.
Keywords: identity amyloid; amyloid plaques; search identity;
Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues
Sign Up to like & getrecommendations! Published in 2024 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.3c00756
Abstract: The accumulation of amyloid plaques and increased brain redox burdens are neuropathological hallmarks of Alzheimer’s disease. Altered metabolism of essential biometals is another feature of Alzheimer’s, with amyloid plaques representing sites of disturbed metal homeostasis.… read more here.
Keywords: brain; chemical; amyloid plaques; iron ... See more keywords
Bifunctional Fluorescent/Raman Nanoprobe for the Early Detection of Amyloid
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43288-2
Abstract: One of the pathological hallmarks of Alzheimer’s disease (AD) is the abnormal aggregation of amyloid beta (Aβ) peptides. Therefore the detection of Aβ peptides and imaging of amyloid plaques are considered as promising diagnostic methods… read more here.
Keywords: detection; amyloid; amyloid plaques; fluorescent raman ... See more keywords
Differentiating Aβ40 and Aβ42 in amyloid plaques with a small molecule fluorescence probe†
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc02060e
Abstract: Differentiating amyloid beta (Aβ) subspecies Aβ40 and Aβ42 has long been considered an impossible mission with small-molecule probes. In this report, based on recently published structures of Aβ fibrils, we designed iminocoumarin–thiazole (ICT) fluorescence probes… read more here.
Keywords: differentiating amyloid; fluorescence; small molecule; amyloid plaques ... See more keywords
The age-specific pathological changes of β-amyloid plaques in the cortex and hippocampus of APP/PS1 transgenic AD mice
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2112368
Abstract: ABSTRACT Objective Numerous pathological variations and complex interactions are involved in the long period prior to cognitive decline in brains with Alzheimer’s disease (AD). Thus, elucidation of the pathological disorders can facilitate early AD diagnosis.… read more here.
Keywords: changes amyloid; age; cortex hippocampus; mice ... See more keywords
Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of innovative optical health sciences"
DOI: 10.1142/s1793545817420019
Abstract: Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the leading cause of dementia worldwide, and is characterized by the accumulation of amyloid plaques in the brain parenchyma. The plaques consist of… read more here.
Keywords: amyloid plaques; brain; transgenic mouse; brillouin microspectroscopy ... See more keywords
High Contrast and Resolution Labeling of Amyloid Plaques in Tissue Sections from APP-PS1 Mice and Humans with Alzheimer’s Disease with the Zinc Chelator HQ-O: Practical and Theoretical Considerations
Sign Up to like & getrecommendations! Published in 2019 at "Current Alzheimer Research"
DOI: 10.2174/1567205016666190725155038
Abstract: Background: Various methodologies have been employed for the localization of amyloid plaques in numerous studies on Alzheimer’s disease. The majority of these stains are thought to label the plaques by virtue of their affinity for… read more here.
Keywords: zinc chelator; zinc; alzheimer disease; amyloid plaques ... See more keywords
Aniracetam: An Evidence-Based Model for Preventing the Accumulation of Amyloid-β Plaques in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-231247
Abstract: Alzheimer’s disease is the leading cause of dementia in the world. It affects 6 million people in the United States and 50 million people worldwide. Alzheimer’s disease is characterized by the accumulation of amyloid-β plaques… read more here.
Keywords: alzheimer disease; amyloid plaques; evidence based; accumulation ... See more keywords