Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202342
Abstract: Abstract Type 2 diabetes mellitus (T2D) is a major public health concern and is characterized by sustained hyperglycemia due to insulin resistance and destruction of insulin‐producing β cells. One pathological hallmark of T2D is the… read more here.
Keywords: protofibril specific; hiapp; human islet; type diabetes ... See more keywords
Graphene quantum dots rescue protein dysregulation of pancreatic β-cells exposed to human islet amyloid polypeptide
Sign Up to like & getrecommendations! Published in 2019 at "Nano Research"
DOI: 10.1007/s12274-019-2520-7
Abstract: The amyloid aggregation of peptides and proteins is a hallmark of neurological disorders and type 2 diabetes. Human islet amyloid polypeptide (IAPP), co-secreted with insulin by pancreatic β-cells, plays dual roles in both glycemic control… read more here.
Keywords: protein expression; islet amyloid; amyloid; human islet ... See more keywords
Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.11.039
Abstract: We have carried out a docking inspired synthesis and screening of a library of diazenyl-derivatives of pyridazinylpyrazolone molecules for their ability to modulate the amyloidogenic self-assembly of human islet amyloid polypeptide (hIAPP). hIAPP is a… read more here.
Keywords: islet amyloid; human islet; synthesis; amyloid polypeptide ... See more keywords
New peptide inhibitors modulate the self‐assembly of islet amyloid polypeptide residues 11–20 in vitro
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.03.015
Abstract: Abstract The structural transition and misfolding of human islet amyloid polypeptide may cause a common metabolic disease Type 2 diabetes mellitus. Seventeen peptides have been synthesized, possessing different lengths, compositions, and peptide conformation. In this… read more here.
Keywords: islet amyloid; peptide; amyloid polypeptide; formation ... See more keywords
Assessing the role of osmolytes on the conformational harmony of islet amyloid polypeptide.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.08.104
Abstract: Several pathological disorders have known linkages with the misfolding and abnormal oligomerization of peptides and proteins and their accumulation into numerous aggregates. One such peptide is human islet amyloid polypeptide (hIAPP) responsible for amyloid aggregation… read more here.
Keywords: aggregation; islet amyloid; hiapp; amyloid polypeptide ... See more keywords
Schiff base oxovanadium complexes resist the assembly behavior of human islet amyloid polypeptide.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2018.05.006
Abstract: The misfolding and fibrillation of human islet amyloid polypeptide (hIAPP) is related to the pathologic process of type II diabetes mellitus (T2DM). The inhibitors of hIAPP aggregation include aromatic organic molecules, short peptides, and metal… read more here.
Keywords: islet amyloid; human islet; amyloid polypeptide; base ... See more keywords
Islet amyloid polypeptide: Another key molecule in Alzheimer’s pathogenesis?
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2017.03.001
Abstract: HighlightsPatients suffering from type 2 diabetes mellitus (T2DM) have an increased risk of developing Alzheimer’s disease (AD).Aggregation of human islet amyloid polypeptide (hIAPP), the pathological hallmark of T2DM, has also been detected in brain tissue… read more here.
Keywords: t2dm; islet amyloid; amyloid polypeptide; pathogenesis ... See more keywords
Nanoparticles and Nanocolloidal Carbon: Will They Be the Next Antidiabetic Class That Targets Fibrillation and Aggregation of Human Islet Amyloid Polypeptide in Type 2 Diabetes?
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00415
Abstract: ConspectusNanotechnology is revolutionizing human medicine. Nanoparticles (NPs) are currently used for treating various cancers, for developing vaccines, and for imaging, and other promises offered by NPs might come true soon. Due to the interplay between… read more here.
Keywords: aggregation; human islet; type diabetes; amyloid polypeptide ... See more keywords
Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.3c00005
Abstract: The aggregation of islet amyloid polypeptide (IAPP) is associated with β-cell dysfunction in type 2 diabetes (T2D) in humans. One possible mechanism of toxicity is the interaction of IAPP oligomers with lipid membranes to disrupt… read more here.
Keywords: pig iapp; iapp; amyloid polypeptide; membrane ... See more keywords
Binuclear ruthenium complexes inhibit the fibril formation of human islet amyloid polypeptide
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DOI: 10.1039/c6ra28107a
Abstract: The deposition of human islet amyloid polypeptide (hIAPP) is closely correlated with type II diabetes mellitus (T2DM). hIAPP misfolding, as a significant causative factor of T2DM, can lead to the failure of islet transplant. Therefore,… read more here.
Keywords: islet amyloid; islet; human islet; hiapp ... See more keywords
His18 promotes reactive oxidative stress production in copper-ion mediated human islet amyloid polypeptide aggregation
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DOI: 10.1039/c9ra09943c
Abstract: Copper ions play a critical role in human islet amyloid polypeptide (hIAPP) aggregation, which has been found in more than 90% of patients with type-2 diabetes (T2D). The role of Cu(II) in the cell cytotoxicity… read more here.
Keywords: islet amyloid; human islet; hiapp; copper ... See more keywords