Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals
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DOI: 10.1093/brain/awac329
Abstract: Abstract Different tau biomarkers become abnormal at different stages of Alzheimer’s disease, with CSF phospho-tau typically becoming elevated at subthreshold levels of tau-PET binding. To capitalize on the temporal order of tau biomarker-abnormality and capture… read more here.
Keywords: tau; tau pet; positive individuals; tau accumulation ... See more keywords
Real-space navigation testing differentiates between amyloid-positive and -negative aMCI
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DOI: 10.1212/wnl.0000000000008758
Abstract: Objective To distinguish between patients with amyloid-positive (A+) and -negative (A−) amnestic mild cognitive impairment (aMCI) by simultaneously investigating navigation performance, visual exploration behavior, and brain activations during a real-space navigation paradigm. Methods Twenty-one patients… read more here.
Keywords: amyloid positive; amci; positive negative; real space ... See more keywords
High Soluble Amyloid-β42 Predicts Normal Cognition in Amyloid-Positive Individuals with Alzheimer’s Disease-Causing Mutations
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DOI: 10.3233/jad-220808
Abstract: Background: In amyloid-positive individuals at risk for Alzheimer’s disease (AD), high soluble 42-amino acid amyloid-β (Aβ42) levels are associated with normal cognition. It is unknown if this relationship applies longitudinally in a genetic cohort. Objective:… read more here.
Keywords: cognition; positive individuals; alzheimer disease; amyloid positive ... See more keywords
Signature of Alzheimer’s Disease in Intestinal Microbiome: Results From the AlzBiom Study
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DOI: 10.3389/fnins.2022.792996
Abstract: Background Changes in intestinal microbiome composition have been described in animal models of Alzheimer’s disease (AD) and AD patients. Here we investigated how well taxonomic and functional intestinal microbiome data and their combination with clinical… read more here.
Keywords: alzbiom study; alzheimer disease; amyloid positive; intestinal microbiome ... See more keywords