Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2018.0629
Abstract: Importance Brain amyloid deposition is a marker of Alzheimer disease (AD) pathology. The population-based prevalence and outcomes of amyloid positivity in a population without dementia are important for understanding the trajectory of amyloid positivity to… read more here.
Keywords: amyloid positivity; population; prevalence; without dementia ... See more keywords
Clinical significance of amyloid β positivity in patients with probable cerebral amyloid angiopathy markers
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04314-7
Abstract: PurposeWe investigated the frequency and clinical significance of amyloid β (Aβ) positivity on PET in patients with cerebral amyloid angiopathy (CAA).MethodsWe recruited 65 patients who met the modified Boston criteria for probable CAA. All underwent… read more here.
Keywords: cerebral amyloid; amyloid positivity; frequency; positivity ... See more keywords
Amyloid-β Positivity Predicts Cognitive Decline but Cognition Predicts Progression to Amyloid-β Positivity
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DOI: 10.1016/j.biopsych.2019.12.021
Abstract: BACKGROUND Stage 1 of the National Institute on Aging-Alzheimer's Association's proposed Alzheimer's disease continuum is defined as amyloid-β (Aβ) positive but cognitively normal. Identifying at-risk individuals before Aβ reaches pathological levels could have great benefits… read more here.
Keywords: amyloid positivity; positivity; biomarker levels; baseline ... See more keywords
Distinct Cognitive Trajectories According to Amyloid Positivity in Non-Alzheimer Disease Dementias
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DOI: 10.1097/rlu.0000000000005457
Abstract: Background The clinical effects of β-amyloid positivity (Aβ+) on copathologies in various dementias remain relatively underexamined. Thus, the present study was conducted to investigate the prevalence and clinical effects of Aβ+ in subcortical vascular cognitive… read more here.
Keywords: cognitive trajectories; amyloid positivity; group; trajectories according ... See more keywords
Establishing cutoff values for visual amyloid positivity in [18F]flutemetamol PET
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DOI: 10.1186/s13550-024-01193-4
Abstract: This study aimed to establish the optimal cutoff values for visual amyloid positivity using standardized uptake value ratios (SUVRs) in [18F]flutemetamol (FMM) positron emission tomography (PET) imaging. Given the variability in amyloid assessment, our goal… read more here.
Keywords: values visual; cutoff values; amyloid positivity; visual amyloid ... See more keywords
Predicting Amyloid Positivity in Cognitively Unimpaired Older Adults: A Machine Learning Approach Using the A4 Data.
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200553
Abstract: OBJECTIVE To develop and test the performance of Positive Aβ Risk Score (PARS) for prediction of Aβ positivity in cognitively unimpaired individuals for use in clinical research. BACKGROUND Detecting β-amyloid (Aβ) positivity is essential for… read more here.
Keywords: pars model; risk; positivity cognitively; positivity ... See more keywords
Association of Caffeine Consumption and Brain Amyloid Positivity in Cognitively Normal Older Adults
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-220591
Abstract: Background: Several epidemiological studies have reported the protective role of caffeine on health outcomes; however, it remained debatable on caffeine consumption and brain amyloid positivity. Objective: We aimed to determine the relationship between caffeine consumption… read more here.
Keywords: amyloid positivity; consumption brain; caffeine consumption; positivity ... See more keywords
CAPS: a simple clinical tool for β-amyloid positivity prediction in clinical Alzheimer syndrome
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2024.1422681
Abstract: Introduction With the advent of anti-β-amyloid therapies, clinical distinction between Aβ + and Aβ− in cognitive impairment is becoming increasingly important for stratifying referral and better utilization of biomarker assays. Methods Cognitive profile, rate of decline, neuropsychiatric… read more here.
Keywords: amyloid positivity; positivity prediction; clinical tool; positivity ... See more keywords