Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
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DOI: 10.1038/s42003-021-02644-7
Abstract: The accumulation of amyloid β (Aβ) in the brain is an established feature of Alzheimer’s disease, however mechanisms that regulate Aβ accumulation are not fully understood. In a recent study, Wang et al show that… read more here.
Keywords: production; amyloid production; beta amyloid; cholesterol ... See more keywords
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease
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DOI: 10.1111/acel.13565
Abstract: Regulation of neuroinflammation and β‐amyloid (Aβ) production are critical factors in the pathogenesis of Alzheimer's disease (AD). Cathepsin E (CatE), an aspartic protease, is widely studied as an inducer of growth arrest and apoptosis in… read more here.
Keywords: neuroinflammation; alzheimer disease; amyloid production; production ... See more keywords
Fucoidan-Rich Substances from Ecklonia cava Improve Trimethyltin-Induced Cognitive Dysfunction via Down-Regulation of Amyloid β Production/Tau Hyperphosphorylation
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DOI: 10.3390/md17100591
Abstract: Ecklonia cava (E. cava) was investigated to compare the effect of polyphenol and fucoidan extract and mixture (polyphenol:fucoidan = 4:6) on cognitive function. The ameliorating effect of E. cava was evaluated using the Y-maze, passive… read more here.
Keywords: amyloid production; production tau; fucoidan; cava ... See more keywords