Label‐free, chronological and selective detection of aggregation and fibrillization of amyloid β protein in serum by microcantilever sensor immobilizing cholesterol‐incorporated liposome
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27380
Abstract: To facilitate the early diagnosis of Alzheimer's disease and mild cognitive impairment patients, we developed a cantilever‐based microsensor that immobilized liposomes of various phospholipids to detect a trace amount of amyloid β (Aβ) protein, and… read more here.
Keywords: amyloid protein; cholesterol; aggregation fibrillization;
Inhibition of Amyloid Protein Aggregation Using Selected Peptidomimetics
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200499
Abstract: Aberrant protein aggregation leads to the formation of amyloid fibrils. This phenomenon is linked to the development of more than 40 irremediable diseases such as Alzheimer's disease, Parkinson's disease, type 2 diabetes, and cancer. Plenty… read more here.
Keywords: aggregation; inhibition amyloid; amyloid protein; protein aggregation ... See more keywords
Amyloid protein produced by B. cereus CR4 possesses bioflocculant activity and has potential application in microalgae harvest
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Letters"
DOI: 10.1007/s10529-019-02758-3
Abstract: Bacillus cereus CR4 from the flocs of activated sludge was found to produce an extracellular bioflocculant, which was characterized as amyloid protein and demonstrated to have potential application in microalgae recovery. Cell surface amyloid production… read more here.
Keywords: cereus cr4; amyloid protein; application; protein produced ... See more keywords
Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid β-protein fibrillation and cytotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers of Chemical Science and Engineering"
DOI: 10.1007/s11705-017-1687-2
Abstract: Amyloid-β (Aβ) protein aggregation is the main hallmark of Alzheimer’s disease (AD). Inhibition of Aβ fibrillation is thus a promising therapeutic approach to the prevention and treatment of AD. Recently, we designed a heptapeptide inhibitor,… read more here.
Keywords: fibrillation; cyclization; head tail; amyloid protein ... See more keywords
Using mirror-image peptides to enhance robustness and reproducibility in studying the amyloid β-protein.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.05.010
Abstract: Alzheimer's disease, the most common form of dementia, is a devastating disease that affects over 44 million people worldwide. One etiological agent of Alzheimer's, the amyloid β-protein (Aβ), is an aggregation-prone, intrinsically disordered peptide that… read more here.
Keywords: mirror image; using mirror; image peptides; amyloid protein ... See more keywords
The p38 mitogen activated protein kinase regulates β-amyloid protein internalization through the α7 nicotinic acetylcholine receptor in mouse brain
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.11.006
Abstract: Alzheimer's disease (AD) is one of the most devastating neurodegenerative disorders. Intracellular β-amyloid protein (Aβ) is an early event in AD. It induces the formation of amyloid plaques and neuron damage. The α7 nicotinic acetylcholine… read more here.
Keywords: internalization; acetylcholine receptor; nicotinic acetylcholine; p38 ... See more keywords
1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid β-protein Oligomer and Fibril Formation.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of mass spectrometry"
DOI: 10.1016/j.ijms.2016.09.018
Abstract: The early oligomerization of amyloid β-protein (Aβ) is a crucial step in the etiology of Alzheimer's disease (AD), in which soluble and highly neurotoxic oligomers are produced and accumulated inside neurons. In search of therapeutic… read more here.
Keywords: terminal metal; penta galloyl; metal binding; galloyl glucopyranose ... See more keywords
Sanweidoukou Decoction, a Chinese herbal formula, ameliorates β-amyloid protein-induced neuronal insult via modulating MAPK/NF-κB signaling pathways: studies in vivo and in vitro.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114002
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The traditional Chinese medicine Sanweidoukou decoction (DK-3) was a classical formula for the treatment of nervous system diseases, recorded in the Chinese medical classic Siku Quanshu. AIM OF THE STUDY The present study… read more here.
Keywords: medicine; signaling pathways; amyloid protein; mapk signaling ... See more keywords
Neuroprotective mechanisms of chronic physical exercise via reduction of β-amyloid protein in experimental models of Alzheimer's disease: A systematic review.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119372
Abstract: AIMS Alzheimer's disease (AD) is the most common irreversible chronic neurodegenerative disease. It is characterized by the abnormal accumulation of β-amyloid protein (Aβ), which triggers homeostatic breakage in several physiological systems. However, the effect of… read more here.
Keywords: alzheimer disease; systematic review; disease; neuroprotective mechanisms ... See more keywords
Amyloid protein aggregation in diabetes mellitus accelerate intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2020.109739
Abstract: Diabetes is one of the risk factors for disc degeneration, but the exact mechanism is still unclear. Misfolding and aggregation of human islet amyloid polypeptide (hIAPP) is an important factor in diabetes. hIAPP proteins misfold… read more here.
Keywords: aggregation; degeneration; amyloid protein; intervertebral disc ... See more keywords
d-Aspartic acid ameliorates painful and neuropsychiatric changes and reduces β-amyloid Aβ1-42 peptide in a long lasting model of neuropathic pain
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.04.041
Abstract: Depressive symptoms and other neuropsychiatric dysfunctions are common in neurodegenerative disorders, including chronic pain and dementia. A correlation between the β-amyloid protein accumulation and the development of depression has been suggested, however the underlying mechanisms… read more here.
Keywords: model neuropathic; amyloid protein; neuropathic pain; long lasting ... See more keywords