Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2019.11.026
Abstract: Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from pathogenic microbes but are also prominent effectors of inflammation and autoimmune disease. T helper 17 (Th17) cells, defined by RORγt-dependent production of IL-17A and… read more here.
Keywords: th17 cells; disease; amyloid proteins; proteins induce ... See more keywords
Single-molecule studies of amyloid proteins: from biophysical properties to diagnostic perspectives
Sign Up to like & getrecommendations! Published in 2020 at "Quarterly Reviews of Biophysics"
DOI: 10.1017/s0033583520000086
Abstract: Abstract In neurodegenerative diseases, a wide range of amyloid proteins or peptides such as amyloid-beta and α-synuclein fail to keep native functional conformations, followed by misfolding and self-assembling into a diverse array of aggregates. The… read more here.
Keywords: single molecule; amyloid proteins; studies amyloid; proteins biophysical ... See more keywords
Multiplex Mass Spectrometry Analysis of Amyloid Proteins in Human Plasma for Alzheimer's Disease Diagnosis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00424
Abstract: Direct analysis of amyloid proteins in human plasma will promote rapid screening of brain amyloidosis, the earliest pathological signature of Alzheimer's disease. We developed a microflow liquid chromatography-targeted mass spectrometry assay for quantitation of four… read more here.
Keywords: proteins human; analysis amyloid; alzheimer disease; human plasma ... See more keywords
MILAMP: Multiple Instance Prediction of Amyloid Proteins
Sign Up to like & getrecommendations! Published in 2021 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2019.2936846
Abstract: Amyloid proteins are implicated in several diseases such as Parkinson's, Alzheimer's, prion diseases, etc. In order to characterize the amyloidogenicity of a given protein, it is important to locate the amyloid forming hotspot regions within… read more here.
Keywords: instance prediction; milamp multiple; amyloid proteins; multiple instance ... See more keywords
Abstract 2888: Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2888
Abstract: INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease for which the 5-year survival rate is about 10%. Rare long-term survivors after surgical resection have been characterized as having high quality immune responses to primary… read more here.
Keywords: cell; amyloid proteins; term survivors; serum amyloid ... See more keywords
The derivatives of cromolyn ameliorate the abnormal misfolding of amyloid proteins and neuroinflammation in the neural cells.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230123101934
Abstract: BACKGROUND The representative symptom of Alzheimer's Disease (AD) has mainly been mentioned to be misfolding of amyloid proteins, such as amyloid-beta (Aβ) and tau protein. In addition, the neurological pathology related to neuroinflammatory signaling has… read more here.
Keywords: cnu 011; amyloid proteins; cnu 010; cnu ... See more keywords
Photo-Oxygenation as a New Therapeutic Strategy for Neurodegenerative Proteinopathies by Enhancing the Clearance of Amyloid Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.945017
Abstract: Alzheimer disease (AD) is associated with the aggregation of two amyloid proteins: tau and amyloid-β (Aβ). The results of immunotherapies have shown that enhancing the clearance and suppressing the aggregation of these two proteins are… read more here.
Keywords: photo oxygenation; amyloid proteins; enhancing clearance; oxygenation ... See more keywords
Direct Identification of Functional Amyloid Proteins by Label-Free Quantitative Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Biomolecules"
DOI: 10.3390/biom7030058
Abstract: Functional amyloids are important structural and functional components of many biofilms, yet our knowledge of these fascinating polymers is limited to a few examples for which the native amyloids have been isolated in pure form.… read more here.
Keywords: functional amyloid; amyloid; free quantitative; amyloid proteins ... See more keywords