Amyloid‐Related Imaging Abnormalities in the DIAN‐TU‐001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26511
Abstract: To determine the characteristics of participants with amyloid‐related imaging abnormalities (ARIA) in a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease (DIAD). read more here.
Keywords: gantenerumab solanezumab; trial; trial gantenerumab; related imaging ... See more keywords
Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit
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DOI: 10.1016/j.nbd.2017.08.015
Abstract: The entorhinal cortex (EC) is affected early in Alzheimer's disease, an illness defined by a co-occurrence of tau and amyloid-related pathologies. How the co-occurrence of these pathologies in the EC affects the hippocampal circuit remains… read more here.
Keywords: entorhinal cortex; amyloid related; hippocampal circuit; tau amyloid ... See more keywords
Aducanumab-Related Amyloid-Related Imaging Abnormalities
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DOI: 10.1097/rlu.0000000000004250
Abstract: Abstract When the FDA granted accelerated approval of Biogen's Alzheimer disease drug, aducanumab (marketed as Aduhelm), it deviated from its mission of guaranteeing drug safety and efficacy because the approval was based exclusively on a… read more here.
Keywords: amyloid; aducanumab related; imaging abnormalities; amyloid related ... See more keywords
Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability
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DOI: 10.3233/jhd-180309
Abstract: The polyglutamine (polyQ) diseases, such as Huntington’s disease and the spinocerebellar ataxias, are characterized by the accumulation of elongated polyQ sequences (epolyQ) and mostly occur during midlife. Considering that polyQ disorders have not been selected… read more here.
Keywords: amyloid related; physiological functions; evolvability; disease ... See more keywords
Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer’s Disease
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DOI: 10.3389/fnins.2020.00266
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the most common cause of dementia. Symptoms of AD include memory loss, disorientation, mood and behavior changes, confusion, unfounded suspicions, and eventually, difficulty speaking, swallowing,… read more here.
Keywords: related rodent; amyloid related; alzheimer disease; hippocampal deficits ... See more keywords