Multistep changes in amyloid structure induced by cross-seeding on a rugged energy landscape.
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DOI: 10.1016/j.bpj.2020.12.005
Abstract: Amyloid fibrils are aberrant protein aggregates associated with various amyloidoses and neurodegenerative diseases. It is recently indicated that structural diversity of amyloid fibrils often results in different pathological phenotypes including cytotoxicity and infectivity. The diverse… read more here.
Keywords: changes amyloid; structure; amyloid fibrils; cross seeding ... See more keywords