Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.43232
Abstract: Key Points Question What is the association between Klotho protein levels in cerebrospinal fluid (CSF) and plasma, heterozygosity status of the KL-VS haplotype, and amyloid and tau burden among cognitively healthy controls and patients with… read more here.
Keywords: amyloid tau; heterozygosity; protein levels; klotho protein ... See more keywords
Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51482
Abstract: Parkinson disease (PD) is defined by the accumulation of misfolded α‐synuclein (α‐syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develop dementia, which… read more here.
Keywords: body dementia; tau accumulation; accumulation; amyloid tau ... See more keywords
Exploring the relationship between physical activity, beta-amyloid and tau: A narrative review
Sign Up to like & getrecommendations! Published in 2019 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2019.01.003
Abstract: Several prospective cohort studies have reported an association between higher levels of physical activity and decreased risk of cognitive decline and dementia, years later. To support physical activity as a preventative measure against dementia, including… read more here.
Keywords: amyloid tau; relationship physical; beta amyloid; physical activity ... See more keywords
Relevance of electroencephalogram assessment in amyloid and tau pathology in rat
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.10.026
Abstract: HighlightsThe rats express in hippocampus beta‐amyloid deposits and phosphorylated tau.On the 3rd month, a working memory impairment is observed by Morris water maze test.On the 3rd week, an overall decrease of the EEG bands power… read more here.
Keywords: amyloid tau; tau; tau pathology; beta amyloid ... See more keywords
Relevance of the interplay between amyloid and tau for cognitive impairment in early Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2019.03.016
Abstract: Amyloid β (Aβ) and tau are key hallmark features of Alzheimer's disease (AD) neuropathology. The interplay of Aβ and tau for cognitive impairment in early AD was examined with cross-sectional analysis, measured by cerebrospinal fluid… read more here.
Keywords: amyloid tau; tau; alzheimer disease; tau cognitive ... See more keywords
Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.04.002
Abstract: Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64-93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1-42… read more here.
Keywords: amyloid tau; cognitively unimpaired; older adults; beyond amyloid ... See more keywords
Relationships between β-amyloid and tau in an elderly population: An accelerated failure time modelww
Sign Up to like & getrecommendations! Published in 2021 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2021.118440
Abstract: Using positron emission tomography (PET)-derived amyloid and tau measurements from 1,495 participants, we explore the evolution of these values over time via an accelerated failure time (AFT) model. The AFT model assumes a shared pattern… read more here.
Keywords: amyloid tau; curve leftward; time; accelerated failure ... See more keywords
A biological classification for Alzheimer’s disease - Amyloid, Tau and Neurodegeneration (A/T/N): results from the Argentine-Alzheimer’s Disease Neuroimaging Initiative
Sign Up to like & getrecommendations! Published in 2019 at "International Psychogeriatrics"
DOI: 10.1017/s1041610219000085
Abstract: Fil: Allegri, Ricardo Francisco. Consejo Nacional de Investigaciones Cientificas y Tecnicas; Argentina. Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia; Argentina. Universidad de la Costa; Colombia read more here.
Keywords: disease amyloid; amyloid tau; biological classification; classification alzheimer ... See more keywords
Synergistic Effect of Amyloid-β and Tau Disrupts Neural Circuits.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00037
Abstract: Alzheimer's disease (AD) is characterized by the coexistence of amyloid-β (Aβ) plaques and tau-based neurofibrillary tangles. Although studies have shown that the interaction between Aβ and tau causes enhanced AD pathology; there is a lack… read more here.
Keywords: amyloid tau; tau; effect amyloid; neural circuits ... See more keywords
Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-019-0478-5
Abstract: As we age, we experience changes in our nighttime sleep and daytime wakefulness. Individuals afflicted with Alzheimer’s disease (AD) can develop sleep problems even before memory and other cognitive deficits are reported. As the disease… read more here.
Keywords: bidirectional relationship; amyloid tau; relationship sleep; alzheimer disease ... See more keywords
Synergy between amyloid-β and tau in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Nature Neuroscience"
DOI: 10.1038/s41593-020-0687-6
Abstract: Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years, the prevailing view of AD pathogenesis has been that changes in Aβ… read more here.
Keywords: amyloid tau; tau alzheimer; alzheimer disease; disease ... See more keywords