Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01168a
Abstract: A series of 2,2'-bipyridine derivatives appended with structurally unique biomolecular auxiliaries were synthesized and investigated for their ability to ameliorate multifaceted amyloid toxicity. Our results highlight the roles of the metal-chelating bipyridine core and functional… read more here.
Keywords: core; toxicity; ameliorate multifaceted; multifaceted amyloid ... See more keywords
Proteasome activity modulates amyloid toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS yeast research"
DOI: 10.1093/femsyr/foac004
Abstract: Alzheimer's Disease (AD) is responsible for 60-80% of identified cases of dementia. While the generation and accumulation of amyloid precursor protein (APP) fragments is accepted as a key step in AD pathogenesis, the precise role… read more here.
Keywords: modulates amyloid; proteasome; activity modulates; activity ... See more keywords
Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0182194
Abstract: Amyloid-beta peptides (Aβ), implicated in Alzheimer's disease (AD), interact with the cellular membrane and induce amyloid toxicity. The composition of cellular membranes changes in aging and AD. We designed multi-component lipid models to mimic healthy… read more here.
Keywords: changes lipid; microscopy; alzheimer disease; amyloid toxicity ... See more keywords
The role of heat shock proteins in preventing amyloid toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1045616
Abstract: The oligomerization of monomeric proteins into large, elongated, β-sheet-rich fibril structures (amyloid), which results in toxicity to impacted cells, is highly correlated to increased age. The concomitant decrease of the quality control system, composed of… read more here.
Keywords: role heat; heat shock; toxicity; preventing amyloid ... See more keywords
Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.00504
Abstract: Our understanding of the molecular processes underlying Alzheimer’s disease (AD) is still limited, hindering the development of effective treatments, and highlighting the need for human-specific models. Advances in identifying components of the amyloid cascade are… read more here.
Keywords: derived neurons; clu; amyloid toxicity; ipsc derived ... See more keywords