α-Synuclein chaperone suppresses nucleation and amyloidogenesis of prion protein.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.120
Abstract: Protein misfolding diseases are a group of devastating disorders characterized by structural conversion of a soluble protein into an amyloid-like aggregate. Typically, the structural conversion occurs by misfolding of a single disease-associated protein, such as… read more here.
Keywords: protein; amyloidogenesis; disease; pathology ... See more keywords
Monitoring Amyloidogenesis with a 3D Deep-Learning-Guided Biolaser Imaging Array.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c03148
Abstract: Amyloidogenesis is a critical hallmark for many neurodegenerative diseases and drug screening; however, identifying intermediate states of protein aggregates at an earlier stage remains challenging. Herein, we developed a peptide-encapsulated droplet microlaser to monitor the… read more here.
Keywords: monitoring amyloidogenesis; amyloidogenesis; amyloidogenesis deep; learning guided ... See more keywords
Conformation-reconstructed multivalent antibody mimic for amplified mitigation of human islet amyloid polypeptide amyloidogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr08090c
Abstract: The misfolding and aggregation of human islet amyloid polypeptide (IAPP) into β-sheet-enriched amyloid fibrils is linked to type 2 diabetes. Antibodies are potent inhibitors of IAPP amyloidogenesis, but their preparation is usually complicated and expensive.… read more here.
Keywords: multivalent antibody; amyloidogenesis; conformation; human islet ... See more keywords