Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia
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DOI: 10.1002/cbic.202500306
Abstract: Nucleophosmin 1(NPM1) is an abundant human protein endowed with many functions where whose dysregulation leads to various cancers and mutations are relevant in acute myeloid leukemia (AML). In the wild‐type form, pentameric NPM1 resides mainly… read more here.
Keywords: acute myeloid; amyloidogenicity; peptidomimetics targeting; amyloid aggregation ... See more keywords
Analysis of Sheep and Goat IAPP Provides Insight into IAPP Amyloidogenicity and Cytotoxicity.
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DOI: 10.1021/acs.biochem.2c00470
Abstract: Human islet amyloid polypeptide (hIAPP) plays a role in glucose regulation but forms pancreatic amyloid deposits in type 2 diabetes, and that process contributes to β-cell dysfunction. Not all species develop diabetes, and not all… read more here.
Keywords: sheep goat; analysis sheep; goat iapp; iapp ... See more keywords
PATH - Prediction of Amyloidogenicity by Threading and Machine Learning
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DOI: 10.1038/s41598-020-64270-3
Abstract: Amyloids are protein aggregates observed in several diseases, for example in Alzheimer’s and Parkinson’s diseases. An aggregate has a very regular beta structure with a tightly packed core, which spontaneously assumes a steric zipper form.… read more here.
Keywords: machine learning; prediction amyloidogenicity; path prediction; amyloidogenicity ... See more keywords