Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
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DOI: 10.1001/jamaneurol.2022.0901
Abstract: Importance The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there is a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin to be a promising agent. Objective To… read more here.
Keywords: neurology; dose methylcobalamin; trial; week ... See more keywords
Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review.
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DOI: 10.1001/jamaneurol.2022.3282
Abstract: Importance Clinical trial activity in amyotrophic lateral sclerosis (ALS) is dramatically increasing; as a result, trial modifications have been introduced to improve efficiency, outcome measures have been reassessed, and considerable discussion about the level of… read more here.
Keywords: lateral sclerosis; end points; primary outcome; amyotrophic lateral ... See more keywords
High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
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DOI: 10.1002/acn3.51501
Abstract: The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% confidence… read more here.
Keywords: incidence; incidence amyotrophic; lateral sclerosis; 2010 2020 ... See more keywords
Alterations in metabolic biomarkers and their potential role in amyotrophic lateral sclerosis
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DOI: 10.1002/acn3.51580
Abstract: Metabolic dysfunction has been suggested to be involved in the pathophysiology of amyotrophic lateral sclerosis (ALS). This study aimed to investigate the potential role of metabolic biomarkers in the progression of ALS and understand the… read more here.
Keywords: lateral sclerosis; potential role; metabolic biomarkers; amyotrophic lateral ... See more keywords
Impact of the National Amyotrophic Lateral Sclerosis Registry: Analysis of Registry‐funded Research
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DOI: 10.1002/acn3.51660
Abstract: This research aims to examine the impact of the National Amyotrophic Lateral Sclerosis (ALS) Registry‐funded research activities. read more here.
Keywords: lateral sclerosis; registry; national amyotrophic; research ... See more keywords
Well‐being on supportive techniques in amyotrophic lateral sclerosis: from neurologists' perspective
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DOI: 10.1002/acn3.51663
Abstract: To investigate intercultural neurologists' perception of well‐being in patients with amyotrophic lateral sclerosis (ALS) using gastrostomy (PEG), non‐invasive, and/or invasive ventilation (NIV/IV) and to analyse the determinants and impact on the management of the above… read more here.
Keywords: techniques amyotrophic; supportive techniques; lateral sclerosis; well supportive ... See more keywords
Analysis of HTT CAG repeat expansion in Italian patients with amyotrophic lateral sclerosis
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DOI: 10.1002/acn3.51673
Abstract: HTT full‐penetrance pathogenic repeat expansions, the genetic cause of Huntington's disease (HD), have been recently reported in a minority of frontotemporal dementia/amyotrophic lateral sclerosis (ALS) patients (0.13%). We analyzed HTT CAG repeats in an Italian… read more here.
Keywords: htt cag; repeat; lateral sclerosis; cag ... See more keywords
Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis
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DOI: 10.1002/acn3.51708
Abstract: To compare serum levels of the astrocyte biomarker glial fibrillary acidic protein (GFAP) in patients with amyotrophic lateral sclerosis (ALS) and neurologically healthy controls and to analyze the relations between serum GFAP (sGFAP) and phenotype… read more here.
Keywords: patients amyotrophic; fibrillary acidic; serum levels; acidic protein ... See more keywords
Cervical spinal cord atrophy in amyotrophic lateral sclerosis across disease stages
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DOI: 10.1002/acn3.51712
Abstract: Spinal cord degeneration is a hallmark of amyotrophic lateral sclerosis. The assessment of gray matter and white matter cervical spinal cord atrophy across clinical stages defined using the King's staging system could advance the understanding… read more here.
Keywords: amyotrophic lateral; lateral sclerosis; cervical spinal; spinal cord ... See more keywords
Dynamic effects of prognostic factors and individual survival prediction for amyotrophic lateral sclerosis disease.
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DOI: 10.1002/acn3.51771
Abstract: OBJECTIVE Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons, with broad heterogeneity in disease progression and survival in different patients. Therefore, an accurate prediction model will be crucial to implement timely interventions… read more here.
Keywords: time; survival; disease; prediction ... See more keywords
Dextromethorphan/quinidine for the treatment of bulbar impairment in amyotrophic lateral sclerosis.
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DOI: 10.1002/acn3.51821
Abstract: OBJECTIVE No efficacious treatments exist to improve or prolong bulbar functions of speech and swallowing in persons with amyotrophic lateral sclerosis (pALS). This study evaluated the short-term impact of dextromethorphan/quinidine (DMQ) treatment on speech and… read more here.
Keywords: bulbar; dextromethorphan quinidine; lateral sclerosis; dmq ... See more keywords