Implications for an imidazol-2-yl carbene intermediate in the rhodanase-catalyzed C-S bond formation reaction of anaerobic ergothioneine biosynthesis.
Sign Up to like & getrecommendations! Published in 2021 at "ACS catalysis"
DOI: 10.1021/acscatal.0c04886
Abstract: In the anaerobic ergothioneine biosynthetic pathway, a rhodanese domain containing enzyme (EanB) activates tne hercynine's sp2 ε-C-H Dona ana replaces it with a C-S bond to produce ergothioneine. The key intermediate for this trans-sulfuration reaction… read more here.
Keywords: anaerobic ergothioneine; carbene intermediate; eanb; reaction ... See more keywords
Structural and Mechanistic Basis for Anaerobic Ergothioneine Biosynthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.2210/pdb6h9a/pdb
Abstract: Ergothioneine is an emergent factor in cellular redox biochemistry in humans and pathogenic bacteria. Broad consensus has formed around the idea that ergothioneine protects cells against reactive oxygen species. The recent discovery that anaerobic microorganisms… read more here.
Keywords: anaerobic ergothioneine; basis anaerobic; structural mechanistic; basis ... See more keywords