Interleukin‐1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D‐HART2)
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cardiology"
DOI: 10.1002/clc.22719
Abstract: Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of confirmed HF cases in the United States. However, there are no highly effective evidence‐based treatments currently available for these patients. Inflammation correlates… read more here.
Keywords: failure preserved; trial; heart; anakinra ... See more keywords
Anakinra in Sanfilippo syndrome: a phase 1/2 trial
Sign Up to like & getrecommendations! Published in 2024 at "Nature Medicine"
DOI: 10.1038/s41591-024-03079-3
Abstract: Sanfilippo syndrome is a fatal childhood neurodegenerative disorder involving neuroinflammation among multiple pathologies. We hypothesized that anakinra, a recombinant interleukin-1 receptor antagonist, could improve neurobehavioral and functional symptoms owing to its capacity to treat neuroinflammation.… read more here.
Keywords: week; phase trial; anakinra; sanfilippo syndrome ... See more keywords
5233Interleukin-1 blockade with Anakinra in ST-segment elevation acute myocardial infarction: Results from the VCUART3 study
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.0079
Abstract: ST-segment elevation myocardial infarction (STEMI) is associated with an intense inflammatory response that predicts an increased risk of death and heart failure (HF). In the current study we tested whether anakinra, a recombinant Interleukin-1 (IL-1)… read more here.
Keywords: segment elevation; myocardial infarction; anakinra; versus ... See more keywords
Steroid-sparing effect of anakinra in giant-cell arteritis: a case series with clinical, biological and iconographic long-term assessments.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab280
Abstract: OBJECTIVES The treatment of giant cell arteritis (GCA) relies on corticosteroids but is burdened by a high rate of relapses and adverse effects. Anti-interleukin-6 treatments show a clear benefit with a significant steroid-sparing effect, but… read more here.
Keywords: giant cell; sparing effect; steroid sparing; cell arteritis ... See more keywords
Spondyloarthritis associated with familial Mediterranean fever: successful treatment with anakinra.
Sign Up to like & getrecommendations! Published in 2017 at "Rheumatology"
DOI: 10.1093/rheumatology/kew290
Abstract: SIR, FMF is an autosomal recessive, autoinflammatory disorder, with mutations in the MEFV gene. The clinical presentation is characterized by recurrent episodes of fever associated with abdominal, chest, joint and muscular pain [1, 2]. Colchicine… read more here.
Keywords: treatment; anakinra; colchicine; spondyloarthritis ... See more keywords
IL‐1 receptor antagonist anakinra downregulates inflammatory cytokines during renal normothermic machine perfusion: Preliminary results
Sign Up to like & getrecommendations! Published in 2024 at "Artificial Organs"
DOI: 10.1111/aor.14909
Abstract: Abstract Background The interleukin 1 (IL‐1) cytokine group plays a key role in sterile inflammation and may be an important target for transplant‐related renal injury. This study examined the effects of anakinra, a non‐specific IL‐1… read more here.
Keywords: normothermic machine; anakinra; receptor antagonist; machine perfusion ... See more keywords
Role of anakinra in the management of children with severe dengue
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2025-329078
Abstract: Objective Severe dengue in children may present with a hyperinflammatory phenotype resembling cytokine storm or secondary haemophagocytic lymphohistiocytosis, characterised by refractory shock, hepatic dysfunction and multiorgan failure. We evaluated the use of interleukin 1 receptor… read more here.
Keywords: dengue; severe dengue; ferritin levels; children severe ... See more keywords
Anakinra for corticosteroid-dependent and colchicine-resistant pericarditis: The IRAP (International Registry of Anakinra for Pericarditis) study
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Preventive Cardiology"
DOI: 10.1177/2047487319879534
Abstract: Aims Novel therapies are needed for recurrent pericarditis, particularly when corticosteroid dependent and colchicine resistant. Based on limited data, interleukin-1 blockade with anakinra may be beneficial. The aim of this multicentre registry was to evaluate… read more here.
Keywords: dependent colchicine; corticosteroid dependent; anakinra; pericarditis ... See more keywords
Tracking Immune Cell Subsets and Activation Profiles in Adults with Haemophagocytic Lymphohistiocytosis Treated with Anakinra
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-197905
Abstract: Introduction HLH is a hyper-inflammatory syndrome characterised by fevers, cytopenias and hemophagocytosis. The IL1-antagonist anakinra is approved by NHS-England, although efficacy across different triggers is unclear. We used full spectral flow cytometry and cytokine analysis… read more here.
Keywords: treatment; cd8 cells; post treatment; post ... See more keywords
A Multi-Centre Study of Outcomes of Anakinra for Trigger Factors of Adult Hemophagocytic Lymphohistiocytosis in England
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-205551
Abstract: Introduction Hemophagocytic Lymphohistiocytosis (HLH) is a rare, lethal hyperinflammatory syndrome. Trigger factors include genetic, auto-immunity, viral infections and blood cancers, commonly lymphoma. The IL1-antagonist anakinra is approved by NHS-England for HLH despite a paucity of… read more here.
Keywords: trigger; trigger factors; hemophagocytic lymphohistiocytosis; blood ... See more keywords
Mortality, cardiac and cerebral damages reduction by IL-1 inhibition in a murine model of TTP.
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood.2023021974
Abstract: Thrombotic thrombocytopenic purpura (TTP), a rare but fatal disease if untreated, is due to alteration in Von Willebrand factor cleavage resulting in capillary microthrombi formation and ischemic organ damage. Interleukin-1 (IL-1), has been shown to… read more here.
Keywords: murine; histology; mortality; ttp ... See more keywords