Investigation of antioxidant and anti‐nociceptive potential of isoxazolone, pyrazolone derivatives, and their molecular docking studies
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21711
Abstract: A series of new isoxazolone (3a–d) and pyrazolone (4a–d) derivatives were synthesized and assessed for their antioxidant and analgesic activity. Among synthesized compounds, 3b and 4b having nitro (NO2) group show high analgesic activity at… read more here.
Keywords: pyrazolone derivatives; analgesic activity; potential isoxazolone; isoxazolone pyrazolone ... See more keywords
Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2-Chromen-4,8-Diols Containing Alkyl-Substituted Aromatic Moieties
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-017-2202-1
Abstract: A series of new heterocyclic compounds with the hexahydro-2H-chromene skeleton were prepared by reacting the monoterpenoid para-mentha-1,8-diene-5,6-diol with 4-alkyl-substituted aromatic aldehydes. Adding small alkyl substituents (methyl and ethyl) to the aldehyde aromatic ring increased the… read more here.
Keywords: activity dimethyl; alkyl substituted; substituted aromatic; synthesis analgesic ... See more keywords
Discovery of a Novel Cysteine Framework XXIV Conotoxin from Conus striatus, S24a, with Potential Analgesic Activity
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-020-10109-4
Abstract: A novel conotoxin, S24a, containing 26 amino acid residues was first derived from the cDNA library of Conus striatus . This conotoxin has the same conserved signal peptide as A-superfamily conotoxins and some unconserved residues… read more here.
Keywords: conus striatus; s24a; potential analgesic; conotoxin ... See more keywords
Conus striatus venom exhibits non-hepatotoxic and non-nephrotoxic potent analgesic activity in mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04875-8
Abstract: Constant research into the pharmaceutical properties of marine natural products has led to the discovery of many potentially active agents considered worthy of medical applications. Genus Conus, which approximately comprises 700 species, is currently under… read more here.
Keywords: crude venom; venom; concentration; analgesic activity ... See more keywords
Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety
Sign Up to like & getrecommendations! Published in 2020 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-020-2795-6
Abstract: Conjugates of terpenoids with 1,3,5-trisubstituted pyrazoles were synthesized by the cross-coupling of methyl 16-(2-chloro-2-oxoacetyl)labdatrienoate with terminal arylacetylenes via the Castro—Stephens reaction and heterocyclization of arylalkyne-1,2-diones with arylhydr-azines. The structure of one reaction product was established… read more here.
Keywords: pyrazoles containing; synthesis analgesic; trisubstituted pyrazoles; analgesic activity ... See more keywords
Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114495
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Allium macrostemon Bunge. is an edible Chinese herb traditionally used for the treatment of thoracic pain, stenocardia, heart asthma and diarrhea. Although its biological potential has been extensively proven such as antioxidant activity,… read more here.
Keywords: macrostemon; nav1 channel; allium macrostemon; analgesic activity ... See more keywords
Phosphonoamidates & Phosphopnoamidines: A convenient Synthesis, Spectroscopic Properties, DFT Calculations & Pharmacological Studies
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DOI: 10.1016/j.molstruc.2021.130321
Abstract: Abstract A series of phosphonoamidates and phosphonoamidines derivatives have been prepared with high yields and their conformations were determined. All compounds were characterized by IR, NMR Spectroscopy (1H, 13C, and 31P) and in some cases… read more here.
Keywords: phosphopnoamidines convenient; analgesic activity; activity; mamp ... See more keywords
S-adenosyl methionine (SAM) attenuates the development of tolerance to analgesic activity of morphine in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.02.054
Abstract: BACKGROUND Development of tolerance to analgesic effect, on chronic administration of morphine, limits its clinical usefulness in pain management. S-adenosyl methionine (SAM) used for arthritis and approved as a supplement in many countries including United… read more here.
Keywords: tolerance; morphine; tolerance analgesic; sam ... See more keywords
Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0067-x
Abstract: Lappaconitine (LA) has been widely used for postoperative and cancer pain control. LA exhibits excellent analgesic activity with a longer effective time than common local anesthetics such as tetracaine and bupivacaine. However, the mechanisms underlying… read more here.
Keywords: voltage; local anesthetics; analgesic activity; gated sodium ... See more keywords
A Co(II) coordination polymer: enhanced fentanyl analgesic activity via reducing glutamate receptor expression
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Coordination Chemistry"
DOI: 10.1080/00958972.2020.1763322
Abstract: Abstract A new Co(II)-containing coordination polymer formulated as [Co(H-ntb)]n (1) has been synthesized via reaction of Co(NO3)2·6H2O with the 4,4′,4′’-nitrilotribenzoate (H3ntb) ligand under solvothermal conditions. In addition, the enhancement of the compound on Fentanyl analgesic… read more here.
Keywords: analgesic activity; coordination polymer; glutamate receptor; fentanyl analgesic ... See more keywords
Screening of analgesic activity of Tunisian Urtica dioica and analysis of its major bioactive compounds by GCMS
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2017.1402352
Abstract: Abstract The present study was aimed to evaluate the analgesic properties of Urtica dioica (UD) and to profile phytochemicals by gas chromatography–mass spectrometry (GC–MS). The ethanolic extracts were prepared by maceration method and extraction using… read more here.
Keywords: analysis; ethanolic extract; analgesic activity; activity ... See more keywords