Discovery of quinoline-derived trifluoromethyl alcohols as antiepileptic and analgesic agents that block sodium channels.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100547
Abstract: The discovery of novel analgesic agents with high potency, low toxicity and low addictive properties remain a priority. This study aims to identify the analgesic potential of quinoline derived α-trifluoromethylated alcohols (QTA) and their mechanism… read more here.
Keywords: quinoline derived; analgesic agents; sodium; antiepileptic analgesic ... See more keywords
Multicenter, Prospective Study of Prehospital Administration of Analgesia in the U.S. Combat Theater of Afghanistan
Sign Up to like & getrecommendations! Published in 2017 at "Prehospital Emergency Care"
DOI: 10.1080/10903127.2017.1335814
Abstract: Abstract Background: Published data on prehospital medical care in combat is limited, likely due to the chaotic and unpredictable nature of care under fire and difficulty in documentation There is limited data on how often… read more here.
Keywords: administration analgesia; combat; analgesic agents; study ... See more keywords
Novel anti-inflammatory and analgesic agents: synthesis, molecular docking and in vivo studies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2018.1426573
Abstract: Abstract Twelve new derivatives of benzothiazole bearing benzenesulphonamide and carboxamide were synthesised and investigated for their in vivo anti-inflammatory, analgesic and ulcerogenic activities. Molecular docking showed an excellent binding interaction of the synthesised compounds with… read more here.
Keywords: anti inflammatory; analgesic agents; 17c 17i; novel anti ... See more keywords
Hybrid Analogues of Hydrazone and Phthalimide: Design, Synthesis, In vivo, In vitro, and In silico Evaluation as Analgesic Agents.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230517121726
Abstract: BACKGROUND Based on the anti-inflammatory and analgesic activity of hydrazone and phthalimide, a new series of hybrid hydrazone and phthalimide pharmacophores was prepared and evaluated as analgesic agents. METHODS The designed ligands were synthesized by… read more here.
Keywords: hybrid analogues; analgesic agents; cox; design ... See more keywords