New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200024
Abstract: Some cyclooxygenase (COX)-2 selective medications were withdrawn from the market just a few years after their production due to cardiovascular side effects. In this study, a new series of pyrimidine/thiazole hybrids 7a-p was synthesized as… read more here.
Keywords: pyrimidine thiazole; cox; analgesic anti; anti inflammatory ... See more keywords
Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.03.011
Abstract: A series of newly synthesized 4-aryl-hydrazonopyrazolones were designed and their structures were confirmed by spectral and elemental analyses. All synthesized compounds were evaluated for their in vitro COXs, 5-LOX inhibition, in vivo analgesic and anti-inflammatory… read more here.
Keywords: anti inflammatory; inflammatory activity; inflammatory; analgesic anti ... See more keywords
Analgesic and anti‐inflammatory controlled‐released injectable microemulsion: Pseudo‐ternary phase diagrams, in vitro, ex vivo and in vivo evaluation
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.12.030
Abstract: Purpose: Development of analgesic and anti‐inflammatory controlled‐released injectable microemulsions utilising lysine clonixinate (LC) as model drug and generally regarded as safe (GRAS) excipients. Methods: Different microemulsions were optimised through pseudo‐ternary phase diagrams and characterised measuring… read more here.
Keywords: anti inflammatory; microemulsion; controlled released; inflammatory controlled ... See more keywords
Design, formulation and evaluation of Chasmanthera dependens Hochst and Chenopodium ambrosioides Linn based gel for its analgesic and anti-inflammatory activities
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04894
Abstract: Background The incidence of pain and inflammation in West Africa and in fact globally, continues to increase at an alarming rate. This research was conducted to investigate the analgesic and anti-inflammatory activities of leaf extracts… read more here.
Keywords: anti inflammatory; herbal gels; chenopodium; analgesic anti ... See more keywords
Evaluation of analgesic and anti-inflammatory actions of indolealkylamines from toad venom in mice using lipidomics and molecular docking.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113677
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Toad venom is one of widely used traditional Chinese medicines due to its analgesic and anti-inflammatory activities. However, hydrophilic alkaloids from toad venom, which may have certain pharmacological activities, have not been systematic… read more here.
Keywords: anti inflammatory; inflammatory actions; toad venom; analgesic anti ... See more keywords
Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2016.08.005
Abstract: The present study was carried out to evaluate analgesic and anti-inflammatory activities in Inula cuspidata stem and root extracts along with heavy metals estimation in stem and root powder. Stem and roots were extracted with… read more here.
Keywords: anti inflammatory; heavy metals; inula cuspidata; analgesic anti ... See more keywords
Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.04.020
Abstract: The premise of the pharmacology of natural product is to explore benefits of natural resources for the mankind. Medicines extracted from natural resources are considered as primary source for drug discovery. Thus, the current study… read more here.
Keywords: anti inflammatory; sativus; safety profile; maxima ... See more keywords
In vivo evaluation of analgesic and anti-inflammatory activity of hydroalcoholic extracts from Handroanthus impetiginosus and their chemical composition by UPLC/MS analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2134861
Abstract: This study demonstrates in vivo analgesic and anti-inflammatory properties of hydroalcoholic extracts of leaves, bark and flowers from the Handroanthus impetiginosus (Bignoniaceae) plant, recognized as 'Ipê roxo' in Brazil. The extracts were evaluated in male Swiss… read more here.
Keywords: hydroalcoholic extracts; anti inflammatory; inflammatory activity; handroanthus impetiginosus ... See more keywords
Analgesic, Anti-inflammatory, Antipyretic, and In Silico Measurements of Sonneratia caseolaris (L.) Fruits from Sundarbans, Bangladesh
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DOI: 10.1155/2022/1405821
Abstract: Sonneratia caseolaris is a widely distributed mangrove plant having much therapeutic importance in traditional medicine. This plant is reported for possessing numerous compounds that are already used for many therapeutic purposes. After finding the presence… read more here.
Keywords: inflammatory antipyretic; silico; anti inflammatory; sonneratia caseolaris ... See more keywords
Evaluation of Analgesic and Anti-inflammatory Activities of Methanolic Leaf and Root Extracts of Gomphocarpus purpurascens A. Rich (Asclepiadaceae) in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Experimental Pharmacology"
DOI: 10.2147/jep.s361194
Abstract: Background Regardless of the availability of drugs many people still experienced pain and inflammation because current medications often trigger potentially serious adverse effects. A range of medicinal plants with analgesic and anti-inflammatory properties have been… read more here.
Keywords: inflammatory activities; root; gomphocarpus purpurascens; anti inflammatory ... See more keywords
Analgesic and Anti-Inflammatory Activities of 80% Methanol Extract and Solvent Fractions of Ehretia cymosa Thonn (Boraginaceae) Leaves in Rodents
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Experimental Pharmacology"
DOI: 10.2147/jep.s396769
Abstract: Background Ethnobotanical studies in various districts of Ethiopia reported that Ehretia cymosa (E. cymosa) is used for the management of headache, abdominal pain, arthritis and rheumatism. However, there is no scientific investigation done so far… read more here.
Keywords: extract solvent; methanol extract; anti inflammatory; solvent fractions ... See more keywords