μ Opioid Receptor-Triggered Notch-1 Activation Contributes to Morphine Tolerance: Role of Neuron–Glia Communication
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01706-6
Abstract: The development of analgesic tolerance to opioids is an important limitation in the management of chronic pain. Spinal cord glial cell activation appears to play a pivotal role in the development and maintenance of opioid… read more here.
Keywords: tolerance; triggered notch; role; activation ... See more keywords
Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101560
Abstract: Morphine is frequently used for pain relief, but long-term morphine therapy in patients with chronic pain results in analgesic tolerance and hyperalgesia. There are no effective therapeutic treatments that limit these detrimental side effects. We… read more here.
Keywords: morphine; analgesic tolerance; nlrp3 inflammasome; inflammasome activation ... See more keywords
A history of ethanol intake accelerates the development of morphine analgesic tolerance: A protective potential for omega-3 fatty acids.
Sign Up to like & getrecommendations! Published in 2022 at "Behavioral neuroscience"
DOI: 10.1037/bne0000542
Abstract: Adolescence is a critical life period during which significant neurodevelopmental changes occur within the central nervous system. Consistently, substance abuse in this stage has been found to induce persistent changes in brain responsiveness to future… read more here.
Keywords: analgesic tolerance; ethanol intake; tolerance; morphine analgesic ... See more keywords
Delta Opioid Receptor in Astrocytes Contributes to Neuropathic Cold Pain and Analgesic Tolerance in Female Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.745178
Abstract: Background: The delta opioid receptor (DOR) contributes to pain control, and a major challenge is the identification of DOR populations that control pain, analgesia, and tolerance. Astrocytes are known as important cells in the pathophysiology… read more here.
Keywords: dor; mice; analgesic tolerance; allodynia ... See more keywords
Analgesic Tolerance Development during Repetitive Electric Stimulations Is Associated with Changes in the Expression of Activated Microglia in Rats with Osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Biomedicines"
DOI: 10.3390/biomedicines8120575
Abstract: Electric stimulation is used for managing osteoarthritic (OA) pain; however, little is known about the development of analgesic tolerance during repeated stimulations and the relation of spinal microglia with OA pain. We investigated the changes… read more here.
Keywords: tolerance; knee joint; activated microglia; expression activated ... See more keywords
The effect of metformin on morphine analgesic tolerance and dependence in rats
Sign Up to like & getrecommendations! Published in 2018 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.235158
Abstract: Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of… read more here.
Keywords: morphine; tolerance; dependence rats; analgesic tolerance ... See more keywords
A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABAARs
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.58364
Abstract: Overactivation of N-methyl-D-aspartate receptor (NMDAR) in the spinal cord dorsal horn (SDH) in the setting of injury represents a key mechanism of neuropathic pain. However, directly blocking NMDAR or its downstream signaling, interaction between postsynaptic… read more here.
Keywords: tolerance; nnos psd; interaction; analgesic tolerance ... See more keywords