Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants
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DOI: 10.3390/ijms23158445
Abstract: The Vitamin D receptor (VDR) plays a key role in calcium homeostasis, as well as in cell proliferation and differentiation. Among the large number of VDR ligands that have been developed, we have previously shown… read more here.
Keywords: vitamin analogs; vdr; analogs bearing; vitamin receptor ... See more keywords
Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study
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DOI: 10.3390/molecules27196457
Abstract: In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when compared to acarbose as a standard drug. The recently… read more here.
Keywords: molecular docking; inhibitory potentials; amylase glucosidase; analogs bearing ... See more keywords