Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.068
Abstract: The RNA-dependent RNA polymerases of Flaviviridae viruses are crucial for replication. The Flaviviridae polymerase is organized into structural motifs (A-G), with motifs F, A, C and E containing interrogating, priming and catalytic substrate-interacting sites. Modified… read more here.
Keywords: flaviviridae viruses; analogue inhibitors; threonine; nucleoside analogue ... See more keywords
Sialidase Inhibitors with Different Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01258
Abstract: Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus… read more here.
Keywords: analogue inhibitors; inhibitors different; product; sialidase ... See more keywords