Structural Consequences of the 1,2,3‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770
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DOI: 10.1002/cmdc.202000220
Abstract: Although the 1,2,3‐triazole is a commonly used amide bioisostere in medicinal chemistry, the structural implications of this replacement have not been fully studied. Employing X‐ray crystallography and computational studies, we report the spatial and electronic… read more here.
Keywords: cystic fibrosis; fibrosis drugs; analogues cystic; amide bioisostere ... See more keywords