Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity
Sign Up to like & getrecommendations! Published in 2018 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2018.07.016
Abstract: In a search of nitric oxide synthase inhibitors with prolonged vasoconstrictive activity, a series of lipophilic cyclohexafused 2-amino-2-thiazolines was obtained via cyclization of tert-butyl- or benzoyl-substituted N-(cyclohex-2-en-1-yl)thioureas. The crystal structure of intermediate N-[(3aRS,7aSR)-3a,4,5,6,7,7a-hexahydro-1,3-benzothiazol-2-yl]benzamide hydrobromide was… read more here.
Keywords: synthesis antihypotensive; analogues enhanced; antihypotensive properties; properties amino ... See more keywords
Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
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DOI: 10.1021/acs.orglett.1c01387
Abstract: Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the… read more here.
Keywords: antifungal; chemical stability; analogues enhanced; antifungal properties ... See more keywords