Syntheses and biological evaluation of BE-43547A2 analogues modified at O35 ester and C15-OH sites
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.12.053
Abstract: Abstract Total syntheses of 6 BE-43547A2 analogues modified at O35 and C15 sites are reported. Late stage oxidation of 15-deoxy-BE-43547A2 delivered 15-epi-BE-43547A2, which verified the proposition that the C15 is an active site for late… read more here.
Keywords: syntheses biological; c15; analogues modified; 43547a2 analogues ... See more keywords
DNA Analogues Modified at the Nonlinking Positions of Phosphorus.
Sign Up to like & getrecommendations! Published in 2020 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.0c00078
Abstract: ConspectusChemically modified oligonucleotides are being developed as a new class of medicines for curing conditions that previously remained untreatable. Three primary classes of therapeutic oligonucleotides are single-stranded antisense oligonucleotides (ASOs), double stranded small interfering RNAs… read more here.
Keywords: dna analogues; dna; modified nonlinking; nonlinking positions ... See more keywords