Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113417
Abstract: NLRP3 inflammasome activation plays a critical role in inflammation and its related disorders. Herein we report a hit-to-lead effort resulting in the discovery of a novel and potent class of NLRP3 inflammasome inhibitors. Among these,… read more here.
Keywords: inflammasome inhibitors; analogues novel; inflammation; discovery chalcone ... See more keywords
Synthesis of ponatinib analogues as novel inhibitors of leukemia stem cells.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0038
Abstract: Aim: To synthesize new analogues of ponatinib and evaluate anti-leukemia cells and cytotoxicity. Methodology & results: The inhibitory activity of compounds 13a and 13c against K562 and HL60 cells was comparable to that of ponatinib… read more here.
Keywords: novel inhibitors; analogues novel; ponatinib analogues; synthesis ponatinib ... See more keywords