Identification of good and bad fragments of tricyclic triazinone analogues as potential PKC-θ inhibitors through SMILES–based QSAR and molecular docking
Sign Up to like & getrecommendations! Published in 2020 at "Structural Chemistry"
DOI: 10.1007/s11224-020-01629-2
Abstract: Based on the mechanism of action of PKC-θ, the inhibition of this enzyme is considered a potential target for the treatment of autoimmune diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis.… read more here.
Keywords: potential pkc; triazinone analogues; pkc inhibitors; pkc ... See more keywords
8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113697
Abstract: β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a… read more here.
Keywords: design synthesis; potential agonists; agonists design; hydroxyquinolin one ... See more keywords
Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00511
Abstract: Misfolding and aggregation of transthyretin are implicated in the fatal systemic disease known as transthyretin amyloidosis. Here, we report the development of a naringenin derivative bearing two chlorine atoms that will be efficacious for preventing… read more here.
Keywords: chlorinated naringenin; transthyretin; analogues potential; potential inhibitors ... See more keywords
Insights into chalcone analogues with potential as antioxidant additives in diesel–biodiesel blends
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DOI: 10.1039/d2ra07300e
Abstract: Biodiesel production is one of the promising strategies to reduce diesel consumption and an important contribution to climate change. However, biodiesel stability remains a challenging problem in biofuel use in the global energy matrix. In… read more here.
Keywords: potential antioxidant; biodiesel blends; analogues potential; diesel biodiesel ... See more keywords
Thiosemicarbazones and analogues as potential biofilm inhibitors of Candida albicans
Sign Up to like & getrecommendations! Published in 2025 at "Biofouling"
DOI: 10.1080/08927014.2025.2457151
Abstract: Abstract Biofilms are a virulence factor for Candida albicans, a common pathogen in human fungal infections, making them resistant to many commercial antifungals. Therefore, the discovery of compounds that inhibit and eradicate biofilms is a… read more here.
Keywords: analogues potential; inhibitors candida; candida albicans; biofilm inhibitors ... See more keywords
The Exploration of Hydromorphone Analogues as Potential Antimalarial Agents
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DOI: 10.2174/0115748855346199250709204122
Abstract: Malaria, a life-threatening disease caused by Plasmodium parasites, still poses a severe threat to public health safety in Africa, South America, and Asia. It is transmitted via Anopheles mosquito bites and has been reported to… read more here.
Keywords: analogues potential; exploration hydromorphone; hydromorphone; hydromorphone analogues ... See more keywords
Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents
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DOI: 10.3390/md20030158
Abstract: In this paper, eight new galaxamide analogues (Z-1~Z-8) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analogue Z-6 displayed… read more here.
Keywords: analogues potential; cyclopeptide galaxamide; galaxamide analogues; galaxamide ... See more keywords