Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial Activity
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DOI: 10.1021/acs.jmedchem.3c00308
Abstract: Brevicidine and laterocidine are macrocyclic lipodepsipeptides with selective activity against Gram-negative bacteria, including colistin-resistant strains. Previously, the macrocyclic core of these peptides was thought essential for antibacterial activity. In this study, we show that C-terminal… read more here.
Keywords: brevicidine laterocidine; analogues retain; activity; antibacterial activity ... See more keywords