Semisynthesis of Hypothemycin Analogues Targeting the C8-C9 Diol.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00434
Abstract: Hypothemycin, an epoxide derivative of (5Z)-7-oxozeaenol, was used in the semisynthesis of a series of C8-C9 diol derivatives, with many inhibiting TAK1 at submicromolar concentrations. A step-economical approach was chosen, whereby nonselective reactions functionalized the… read more here.
Keywords: semisynthesis; hypothemycin analogues; hypothemycin; targeting diol ... See more keywords
In silico studies of ASEM analogues targeting α7-nAChR and experimental verification
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra10435c
Abstract: The in silico binding free energies of the ASEM analogues targeting α7-nAChR are in line with the inhibition obtained from in vitro binding assays. read more here.
Keywords: silico studies; targeting nachr; analogues targeting; asem analogues ... See more keywords