Structural and bioinformatics analyses identify deoxydinucleotide-specific nucleases and their association with genomic islands in gram-positive bacteria
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae1235
Abstract: Abstract Dinucleases of the DEDD superfamily, such as oligoribonuclease, Rexo2 and nanoRNase C, catalyze the essential final step of RNA degradation, the conversion of di- to mononucleotides. The active sites of these enzymes are optimized… read more here.
Keywords: genomic islands; identify deoxydinucleotide; bioinformatics analyses; analyses identify ... See more keywords
Network analyses identify liver‐specific targets for treating liver diseases
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Systems Biology"
DOI: 10.15252/msb.20177703
Abstract: We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first generated co‐expression networks (CNs) for 46 human tissues and liver cancer to… read more here.
Keywords: liver specific; liver diseases; liver; analyses identify ... See more keywords
Proteomic Analyses Identify Therapeutic Targets in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.814120
Abstract: Hepatocellular carcinoma (HCC) is the fourth cause of cancer-related mortality worldwide. While many targeted therapies have been developed, the majority of HCC tumors do not harbor clinically actionable mutations. Protein-level aberrations, especially those not evident… read more here.
Keywords: hepatocellular carcinoma; proteomic analyses; identify therapeutic; targets hepatocellular ... See more keywords