Multiplex PCR and NGS-based identification of mRNA splicing variants: Analysis of BRCA1 splicing pattern as a model.
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DOI: 10.1016/j.gene.2017.09.025
Abstract: Alternative pre-mRNA splicing increases transcriptome plasticity by forming naturally-occurring alternative splicing variants (ASVs). Alterations of splicing processes, caused by DNA mutations, result in aberrant splicing and the formation of aberrant mRNA isoforms. Analyses of hereditary… read more here.
Keywords: analysis brca1; mrna splicing; splicing variants; multiplex pcr ... See more keywords