Comprehensive analysis of T‐cell receptor repertoires reveals antigen‐driven T‐cell clusters in patients with Behçet's syndrome
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250181
Abstract: T lymphocytes are the major components of adaptive immunity in Behçet's syndrome (BS) pathology. However, the precise mechanism of T‐cell‐induced inflammatory condition remains to be determined. We applied bulk sequencing of the T‐cell receptor (TCR)… read more here.
Keywords: analysis cell; cell; beh syndrome; cell receptor ... See more keywords
An original methodology to study polymeric nanoparticle-macrophage interactions: nanoparticle tracking analysis in cell culture media and quantification of the internalized objects.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121202
Abstract: Poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) are among the most employed (co)polymers for the preparation of drug nanocarriers for the treatment of cancer and infectious diseases. Before considering any clinical use, it is necessary… read more here.
Keywords: methodology; cell culture; culture media; cell ... See more keywords
A comparative analysis of cell surface targeting aptamers
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26463-w
Abstract: Aptamers represent a potentially important class of ligands for the development of diagnostics and therapeutics. However, it is often difficult to compare the function and specificity of many of these molecules as assay formats and… read more here.
Keywords: comparative analysis; aptamer binding; cell surface; cell ... See more keywords
Integrative spatial analysis of cell morphologies and transcriptional states with MUSE.
Sign Up to like & getrecommendations! Published in 2022 at "Nature biotechnology"
DOI: 10.1038/s41587-022-01251-z
Abstract: Spatial transcriptomics enables the simultaneous measurement of morphological features and transcriptional profiles of the same cells or regions in tissues. Here we present multi-modal structured embedding (MUSE), an approach to characterize cells and tissue regions… read more here.
Keywords: cell morphologies; integrative spatial; spatial analysis; transcriptional states ... See more keywords
The Glycosyltransferase Pathway: An Integrated Analysis of the Cell Metabolome
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12101006
Abstract: Nucleotide sugar-dependent glycosyltransferases (UGTs) are critical to the homeostasis of endogenous metabolites and the detoxification of xenobiotics. Their impact on the cell metabolome remains unknown. Cellular metabolic changes resulting from human UGT expression were profiled… read more here.
Keywords: analysis cell; glycosyltransferase pathway; cell metabolome; pathway integrated ... See more keywords