Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline.
Sign Up to like & getrecommendations! Published in 2021 at "Nature protocols"
DOI: 10.1038/s41596-021-00596-0
Abstract: The continued improvement of combinatorial CRISPR screening platforms necessitates the development of new computational pipelines for scoring combinatorial screening data. Unlike for single-guide RNA (sgRNA) pooled screening platforms, combinatorial scoring for multiplexed systems is confounded… read more here.
Keywords: crispr; screens orthrus; combinatorial crispr; screening data ... See more keywords
Differential analysis of combinatorial protein complexes with CompleXChange
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-2852-z
Abstract: BackgroundAlthough a considerable number of proteins operate as multiprotein complexes and not on their own, organism-wide studies so far are only able to quantify individual proteins or protein-coding genes in a condition-specific manner for a… read more here.
Keywords: differential analysis; analysis; protein complexes; analysis combinatorial ... See more keywords