Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function
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DOI: 10.1371/journal.pgen.1011750
Abstract: A hallmark of the highly conserved CYP4B1 enzyme in mammals is the capability to bioactivate both xenobiotic and endobiotic substrates. However, due to a single amino acid change (p.P427S) within the evolutionary conserved meander region… read more here.
Keywords: apes humans; function; cyp4b1; analysis cyp4b1 ... See more keywords