Clustering analysis revealed the autophagy classification and potential autophagy regulators' sensitivity of pancreatic cancer based on multi‐omics data
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4932
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is unresponsive to conventional therapeutic modalities due to its high heterogeneity, expounding the necessity, and priority of searching for effective biomarkers and drugs. Autophagy, as an… read more here.
Keywords: revealed autophagy; analysis revealed; clustering analysis; classification potential ... See more keywords
Isotopic Labeling-Enabled Chemical Proteomics Analysis Revealed Structural and Functional Features of Allysine Modifications in Mammalian Cells and Tissues.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c00660
Abstract: Allysine is a pivotal protein post-translational modification that regulates protein interaction and activities. It is also recognized as a marker of oxidative stress under certain metabolic and physiological conditions. In this study, we developed a… read more here.
Keywords: analysis; analysis revealed; isotopic labeling; chemical proteomics ... See more keywords
Assessment of the effectiveness of intranasal antiviral therapies in preclinical SARS-CoV-2 infection mouse models: a systematic review
Sign Up to like & getrecommendations! Published in 2025 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2025.2522250
Abstract: ABSTRACT Introduction Intranasally (IN) administered antiviral therapies have emerged as a promising approach to combating SARS-CoV-2 respiratory tract infections. This systematic review aims to examine published preclinical animal studies that report anti-SARS-CoV-2 effects due to… read more here.
Keywords: sars cov; therapies preclinical; systematic review; analysis revealed ... See more keywords
An in silico analysis revealed a novel evolutionary lineage of putative mitoviruses.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental microbiology"
DOI: 10.1111/1462-2920.16202
Abstract: Mitoviruses (family Mitoviridae) are small capsid-less RNA viruses that replicate in the mitochondria of fungi and plants. However, to date, the only authentic animal mitovirus infecting an insect was identified as Lutzomyia longipalpis mitovirus 1… read more here.
Keywords: novel evolutionary; putative mitoviruses; analysis revealed; lineage ... See more keywords
Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14160
Abstract: Children with Down syndrome (DS) are at a 20‐fold increased risk for acute lymphoblastic leukemia (ALL). Compared to children with ALL and no DS (non‐DS‐ALL), those with DS and ALL (DS‐ALL) harbor uncommon genetic alterations,… read more here.
Keywords: epigenetic analysis; lymphoblastic leukemia; integrated genetic; acute lymphoblastic ... See more keywords
Diastolic Cardiomyopathy Secondary to Experimentally Induced Exacerbated Emphysema.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0382oc
Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a clinical entity of increasing significance. COPD involves abnormalities of the airways and in emphysema, parenchymal pulmonary destruction. Cardiovascular disease has emerged as a significant comorbidity to COPD. Heart… read more here.
Keywords: copd; vivo; analysis revealed; diastolic cardiomyopathy ... See more keywords
Microstructural and chemical properties of gari and eba: Food products from cassava (Manihot esculenta Cranz)
Sign Up to like & getrecommendations! Published in 2021 at "Food Science and Technology International"
DOI: 10.1177/1082013221993607
Abstract: The microstructure, elemental distribution and rheological behavior of two varieties of gari and their doughs (eba) were investigated. SEM analysis revealed a concave structure with fibre-strands, which were altered after processing to eba. Gari nanostructures… read more here.
Keywords: food; analysis revealed; microstructural chemical; chemical properties ... See more keywords
Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-020-07456-2
Abstract: Background Treating patients with advanced sarcomas is challenging due to great histologic diversity among its subtypes. Leiomyosarcoma (LMS) and de-differentiated liposarcoma (DDLPS) are two common and aggressive subtypes of soft tissue sarcoma (STS). They differ… read more here.
Keywords: lms ddlps; fusion events; differentiated liposarcoma; analysis revealed ... See more keywords
Transcriptomic analysis revealed ferroptosis in ducklings with splenic necrosis induced by NDRV infection
Sign Up to like & getrecommendations! Published in 2025 at "Veterinary Research"
DOI: 10.1186/s13567-025-01479-y
Abstract: Infection with novel duck reovirus (NDRV) results in severe splenic necrosis, leading to immunosuppression, secondary infections with other pathogens, and impairment of the immune effect of the vaccine. However, little is known about NDRV-induced spleen… read more here.
Keywords: ndrv infection; analysis revealed; ferroptosis; infection ... See more keywords
Transcriptome analysis revealed the mechanism of Luciobarbus capito (L. capito) adapting high salinity: Antioxidant capacity, heat shock proteins, immunity.
Sign Up to like & getrecommendations! Published in 2023 at "Marine pollution bulletin"
DOI: 10.2139/ssrn.4384882
Abstract: Salinity has a significant influence on the physiology of freshwater aquatic organisms. However, there are few studies on the hematology and immunology of freshwater fish under high salinity. In the current study, we aimed to… read more here.
Keywords: signaling pathway; high salinity; analysis revealed; salinity ... See more keywords
Multi-omics analysis revealed the role of CCT2 in the induction of autophagy in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.967730
Abstract: Chaperonin containing TCP1 subunit 2 (CCT2) is essential in various neurodegenerative diseases, albeit its role in the pathogenesis of Alzheimer’s disease (AD) remains elusive. This study aimed to evaluate the role of CCT2 in Alzheimer’s… read more here.
Keywords: disease; alzheimer disease; role cct2; analysis revealed ... See more keywords