Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4933
Abstract: Non‐small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the most frequently diagnosed histological subtypes. Multi‐modal omics profiling has been carried… read more here.
Keywords: lung cancer; metabolomics transcriptomics; transcriptomics analysis; integrative metabolomics ... See more keywords
Chiral NMR analysis reveals the environmental dependence of areolal scalemization in Piptothrix areolare.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23436
Abstract: The occurrence of racemic and enantiomerically enriched (scalemic) mixtures of secondary metabolites in their natural sources is a rare phenomenon. The unprecedent case of enantiomeric variations from levorotatory to dextrorotatory, and back to levorotatory, passing… read more here.
Keywords: piptothrix areolare; nmr analysis; chiral nmr; analysis ... See more keywords
Betacoronaviruses genome analysis reveals evolution toward specific codons usage: Implications for SARS‐CoV‐2 mitigation strategies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27056
Abstract: Since the start of the coronavirus disease 2019 (COVID‐19) pandemic, the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has rapidly widespread worldwide becoming one of the major global public health issues of the last centuries.… read more here.
Keywords: analysis reveals; betacoronaviruses genome; analysis; codon usage ... See more keywords
Metabolomic analysis reveals the influences of IC50 vitamin D3 on RAW264.7 cells based on 1 H NMR and UPLC-MS/MS.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11882
Abstract: BACKGROUND As a lipid-soluble vitamin necessary for normal human physiology, vitamin D is mostly used in fortified foods, medicines, and adjuvant treatment of diseases. However, taken in high doses, vitamin D can be toxic. METHODS… read more here.
Keywords: nmr uplc; analysis reveals; ic50 vitamin; metabolomic analysis ... See more keywords
Proteomic Analysis Reveals Anti‐Fibrotic Effects of Blue Light Photobiomodulation on Fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "Lasers in Surgery and Medicine"
DOI: 10.1002/lsm.23137
Abstract: This study was aimed at determining the effects of blue light photobiomodulation on primary adult mouse dermal fibroblasts (AMDFs) and the associated signaling pathways. read more here.
Keywords: blue light; analysis reveals; light photobiomodulation; effects blue ... See more keywords
Genome-wide analysis reveals the evolution and structural features of WRINKLED1 in plants
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-018-1512-8
Abstract: WRINKLED1 (WRI1), an AP2/ERE transcription factor, is one of the most important regulators of oil accumulation. It has been extensively studied in angiosperms, but its evolution and overview features in plants remain unknown. In this… read more here.
Keywords: analysis reveals; genome wide; evolution; vascular plants ... See more keywords
Metatranscriptomic analysis reveals active microbes and genes responded to short-term Cr(VI) stress
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology"
DOI: 10.1007/s10646-020-02290-5
Abstract: Heavy metals have been severely polluting the environment. However, the response mechanism of microbial communities to short-term heavy metals stress remains unclear. In this study, metagenomics (MG) and metatranscriptomics (MT) was performed to observe the… read more here.
Keywords: analysis reveals; term stress; term; short term ... See more keywords
A quantitative yeast aging proteomics analysis reveals novel aging regulators.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00412-3
Abstract: Calorie restriction (CR) is the most robust longevity intervention, extending lifespan from yeast to mammals. Numerous conserved pathways regulating aging and mediating CR have been identified; however, the overall proteomic changes during these conditions remain… read more here.
Keywords: analysis reveals; aging proteomics; proteomics analysis; quantitative yeast ... See more keywords
Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.02.036
Abstract: Summary Considerable work has linked hormone receptors, such as estrogen receptor-alpha (ER), with the pioneer factor FOXA1. Altered FOXA1 levels contribute to endocrine-resistant breast cancer, where it maintains ER-chromatin interactions, even in contexts in which… read more here.
Keywords: analysis reveals; comprehensive genomic; foxa1 binding; foxa1 ... See more keywords
SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.049
Abstract: SUMMARY Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senescence-associated secretory phenotype (SASP) that participates in several age-related diseases. Using stable isotope labeling with amino acids (SILACs) and cultured cells, we identify 343… read more here.
Keywords: analysis reveals; senescent cells; senescence; cellular senescence ... See more keywords
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.08.010
Abstract: We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode… read more here.
Keywords: analysis reveals; tgf superfamily; pan cancer; cancer analysis ... See more keywords