Computational Methods for Analysis of Tumor Clonality and Evolutionary History.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8868-6_13
Abstract: Cancer is an evolutionary process. Recent advances in sequencing technologies have allowed us to investigate intratumor heterogeneity at the single nucleotide level. Here, we describe computational methods that use sequencing data to identify genetically distinct… read more here.
Keywords: clonality evolutionary; tumor clonality; methods analysis; computational methods ... See more keywords
ATHENA: analysis of tumor heterogeneity from spatial omics measurements
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac303
Abstract: Abstract Summary Tumor heterogeneity has emerged as a fundamental property of most human cancers, with broad implications for diagnosis and treatment. Recently, spatial omics have enabled spatial tumor profiling, however computational resources that exploit the… read more here.
Keywords: tumor heterogeneity; heterogeneity; analysis tumor; heterogeneity spatial ... See more keywords
JCDSA: a joint covariate detection tool for survival analysis on tumor expression profiles
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DOI: 10.1186/s12859-018-2213-3
Abstract: BackgroundSurvival analysis on tumor expression profiles has always been a key issue for subsequent biological experimental validation. It is crucial how to select features which closely correspond to survival time. Furthermore, it is important how… read more here.
Keywords: covariate detection; expression profiles; expression; analysis tumor ... See more keywords
Gene expression analysis of tumor biopsies from a trial of durvalumab to identify subsets of NSCLC with shared immune pathways.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3041
Abstract: 3041Background: We previously reported that NSCLC pts with high pretreatment tumoral IFNG mRNA signature (sig) expression have improved outcomes (ORR, PFS, OS) to the anti-PD-L1 therapy durvalumab ... read more here.
Keywords: expression analysis; biopsies trial; gene expression; expression ... See more keywords
Geostatistical Modeling and Heterogeneity Analysis of Tumor Molecular Landscape
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DOI: 10.3390/cancers14215235
Abstract: Simple Summary The present study introduces a new computational platform referred to as GATHER to conduct Geostatistical Analysis of Tumor Heterogeneity and Entropy in R. GATHER has several distinct advantages such as (a) a novel… read more here.
Keywords: heterogeneity; analysis tumor; geostatistical modeling; tumor ... See more keywords