Computational Methods for Analysis of Tumor Clonality and Evolutionary History.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8868-6_13
Abstract: Cancer is an evolutionary process. Recent advances in sequencing technologies have allowed us to investigate intratumor heterogeneity at the single nucleotide level. Here, we describe computational methods that use sequencing data to identify genetically distinct… read more here.
Keywords: clonality evolutionary; tumor clonality; methods analysis; computational methods ... See more keywords
ATHENA: analysis of tumor heterogeneity from spatial omics measurements
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac303
Abstract: Abstract Summary Tumor heterogeneity has emerged as a fundamental property of most human cancers, with broad implications for diagnosis and treatment. Recently, spatial omics have enabled spatial tumor profiling, however computational resources that exploit the… read more here.
Keywords: tumor heterogeneity; heterogeneity; analysis tumor; heterogeneity spatial ... See more keywords
Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling.
Sign Up to like & getrecommendations! Published in 2024 at "Cancer research"
DOI: 10.1158/0008-5472.can-23-2268
Abstract: AXIN1 is a major component of the β-catenin destruction complex and is frequently mutated in various cancer types, particularly liver cancers. Truncating AXIN1 mutations are recognized to encode a defective protein that leads to β-catenin… read more here.
Keywords: missense mutations; analysis; catenin; catenin signaling ... See more keywords
JCDSA: a joint covariate detection tool for survival analysis on tumor expression profiles
Sign Up to like & getrecommendations! Published in 2018 at "BMC Bioinformatics"
DOI: 10.1186/s12859-018-2213-3
Abstract: BackgroundSurvival analysis on tumor expression profiles has always been a key issue for subsequent biological experimental validation. It is crucial how to select features which closely correspond to survival time. Furthermore, it is important how… read more here.
Keywords: covariate detection; expression profiles; expression; analysis tumor ... See more keywords
Gene expression analysis of tumor biopsies from a trial of durvalumab to identify subsets of NSCLC with shared immune pathways.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3041
Abstract: 3041Background: We previously reported that NSCLC pts with high pretreatment tumoral IFNG mRNA signature (sig) expression have improved outcomes (ORR, PFS, OS) to the anti-PD-L1 therapy durvalumab ... read more here.
Keywords: expression analysis; biopsies trial; gene expression; expression ... See more keywords
Analysis of tumor detection using polydimethylsiloxane based wearable antenna
Sign Up to like & getrecommendations! Published in 2024 at "Frequenz"
DOI: 10.1515/freq-2023-0384
Abstract: Abstract A Polydimethylsiloxane (PDMS) based antenna is designed for skin tumor detection. The antenna functions at 2.45 GHz with a bandwidth of 2.30–2.64 GHz working in the ISM (Industrial, Scientific, and Medical) band. The size of the… read more here.
Keywords: polydimethylsiloxane; antenna; tumor; analysis tumor ... See more keywords
Geostatistical Modeling and Heterogeneity Analysis of Tumor Molecular Landscape
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215235
Abstract: Simple Summary The present study introduces a new computational platform referred to as GATHER to conduct Geostatistical Analysis of Tumor Heterogeneity and Entropy in R. GATHER has several distinct advantages such as (a) a novel… read more here.
Keywords: heterogeneity; analysis tumor; geostatistical modeling; tumor ... See more keywords