Analytical challenges in the assessment of NO synthesis from L-arginine in the MELAS syndrome.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.12.036
Abstract: Article history: Received 29 November 2016 Accepted 16 December 2016 Available online xxxx and of de novo synthesized N2-ADMA. Arg's compartmentalization [5] and concomitant conversion of infused N2-Arg to L-N2homoarginine and N2-guanidinoacetate alter Arg's metabolism… read more here.
Keywords: analytical challenges; challenges assessment; assessment synthesis; melas syndrome ... See more keywords
Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.xphs.2018.08.012
Abstract: In this study, we investigated analytical challenges associated with the formulation of 2 anti-HIV broadly neutralizing antibodies (bnAbs), 3BNC117 and PGT121, both separately at 100 mg/mL and together at 50 mg/mL each. The bnAb formulations… read more here.
Keywords: stability studies; analytical challenges; 3bnc117 pgt121; neutralizing antibodies ... See more keywords
Analytical Challenges and Recent Advances in Mass Spectrometry Based Lipidomics.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b04836
Abstract: Although no internationally accepted consensus definition exists, lipids can be broadly defined as “fatty acids and their derivatives, and substances related biosynthetically or functionally to these compounds”. Lipids play critical roles as (i) the major… read more here.
Keywords: advances mass; mass spectrometry; analytical challenges; challenges recent ... See more keywords
Analytical Challenges and Opportunities For Indoor Air Chemistry Field Studies.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b00277
Abstract: Despite the vast time humans spend indoors, indoor air is far less well chemically characterized than the outdoor atmosphere. Advanced instrumentation for measurement of reactive trace gases, particles, and surfaces is enabling a renaissance in… read more here.
Keywords: challenges opportunities; air chemistry; analytical challenges; chemistry ... See more keywords
Analytical Challenges and Metrological Approaches to Ensuring Dietary Supplement Quality: International Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.714434
Abstract: The increased utilization of metrology resources and expanded application of its’ approaches in the development of internationally agreed upon measurements can lay the basis for regulatory harmonization, support reproducible research, and advance scientific understanding, especially… read more here.
Keywords: quality; supplement; data management; analytical challenges ... See more keywords
Analytical Challenges in Diabetes Management: Towards Glycated Albumin Point-of-Care Detection
Sign Up to like & getrecommendations! Published in 2022 at "Biosensors"
DOI: 10.3390/bios12090687
Abstract: Diabetes mellitus is a worldwide-spread chronic metabolic disease that occurs when the pancreas fails to produce enough insulin levels or when the body fails to effectively use the secreted pancreatic insulin, eventually resulting in hyperglycemia.… read more here.
Keywords: point care; analytical challenges; challenges diabetes; glycated albumin ... See more keywords
Overcoming analytical challenges to generate data critical to understanding lipid nanoparticle-delivered modified mRNA biodistribution.
Sign Up to like & getrecommendations! Published in 2019 at "Bioanalysis"
DOI: 10.4155/bio-2019-0138
Abstract: Aim: Chemically modified mRNA offers a novel approach to treat disease. Due to susceptibility to extracellular nucleases in vivo, dosed modified mRNA therapeutics can benefit from encapsulation within novel delivery systems, such as lipid nanoparticles… read more here.
Keywords: biodistribution; modified mrna; overcoming analytical; analytical challenges ... See more keywords