Analytical and functional aspects of protein-ligand interactions: Beyond induced fit and conformational selection.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.109064
Abstract: Ligand-dependent changes in protein conformation are foundational to biology. Historical mechanistic models for substrate-specific proteins are induced fit (IF) and conformational selection (CS), which invoke a change in protein conformation after ligand binds or before… read more here.
Keywords: protein; conformational selection; analytical functional; induced fit ... See more keywords
Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb
Sign Up to like & getrecommendations! Published in 2023 at "mAbs"
DOI: 10.1080/19420862.2022.2160227
Abstract: ABSTRACT The clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As mAb-based… read more here.
Keywords: order structure; correlated analytical; higher order; analytical functional ... See more keywords