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Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27741
Abstract: Process analytical technology (PAT) is a fast‐growing field within bioprocessing that enables innovation in biological drug manufacturing. This study demonstrates novel PAT methods for monitoring multiple quality attributes simultaneously during the ultrafiltration and diafiltration (UF/DF)…
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Keywords:
quality attributes;
line;
analytical technology;
single use ... See more keywords
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Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2758
Abstract: A major challenge in chromatography purification of therapeutic proteins is batch‐to‐batch variability with respect to impurity levels and product concentration in the feed. Mechanistic model can enable process analytical technology (PAT) implementation by predicting impact…
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Keywords:
chromatography;
hydrophobic interaction;
analytical technology;
model ... See more keywords
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Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2021.106215
Abstract: Abstract The goal of this article is to guide the reader through the critical points to be faced when monitoring a fermentation following a Process Analytical Technology (PAT) approach. To achieve this purpose Attenuated Total…
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Keywords:
atr mir;
mir spectroscopy;
spectroscopy;
process analytical ... See more keywords
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Published in 2018 at "Journal of Chemical Education"
DOI: 10.1021/acs.jchemed.8b00725
Abstract: Process analytical technologies (PATs) are used in the pharmaceutical and other industries to monitor chemical processes in real-time with analytical instrumentation. Each PAT analyzer brings its own advantages and disadvantages to the process, and multiplexing…
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Keywords:
vis spectroscopy;
analytical technology;
monitoring;
spectroscopy ... See more keywords
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Published in 2023 at "Artificial Intelligence"
DOI: 10.15407/jai2023.01.049
Abstract: In the 21st century, one of the most widespread problems in developed countries is the unraveling of complex tasks related to the security of citizens. An example is the need to conduct a security check…
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Keywords:
analytical technology;
technology;
technology monitoring;
monitoring flow ... See more keywords
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Published in 2019 at "Foods"
DOI: 10.3390/foods8090405
Abstract: Failures in milk coagulation during cheese manufacturing can lead to decreased yield, anomalous behaviour of cheese during storage, significant impact on cheese quality and process wastes. This study proposes a Process Analytical Technology approach based…
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Keywords:
milk;
control;
analytical technology;
process ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25061362
Abstract: The great challenge facing humanity in the coming decades is to secure food for the 9 [...].
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Keywords:
analytical technology;
nutrition analysis;
technology nutrition;
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154846
Abstract: The release of the FDA’s guidance on Process Analytical Technology has motivated and supported the pharmaceutical industry to deliver consistent quality medicine by acquiring a deeper understanding of the product performance and process interplay. The…
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Keywords:
analytical technology;
fusion;
data fusion;
challenges opportunities ... See more keywords