Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.01.032
Abstract: Summary The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC). APC/C triggers ubiquitination of Securin and Cyclin B, which leads to loss of… read more here.
Keywords: anaphase; mad2 independent; sgo2 dependent; mad2 ... See more keywords
The Aurora B gradient sustains kinetochore stability in anaphase
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DOI: 10.1016/j.celrep.2021.109818
Abstract: Summary Kinetochores assemble on chromosomes in mitosis to allow microtubules to attach and bring about accurate chromosome segregation. The kinases Cyclin B-Cdk1 and Aurora B are crucial for the formation of stable kinetochores. However, the… read more here.
Keywords: aurora gradient; anaphase; kinetochore stability; stability anaphase ... See more keywords
SUMO targets the APC/C to regulate transition from metaphase to anaphase
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03486-4
Abstract: Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in… read more here.
Keywords: anaphase; mitosis; transition; metaphase anaphase ... See more keywords
Sister chromatids separate during anaphase in a three-stage program as directed by interaxis bridges
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123363119
Abstract: Significance A central feature of mitosis is segregation of sister chromatids to opposite poles during anaphase. Our recent work revealed that sister chromatids are linked by robust structural bridges built on topological sister/sister catenations. This… read more here.
Keywords: sister chromatids; chromatids separate; anaphase; three stage ... See more keywords
CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes
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DOI: 10.1242/jcs.238105
Abstract: ABSTRACT Oocyte meiotic maturation failure is one of the major causes for female infertility. Meiotic resumption (the G2/M transition) and progression through metaphase I (MI) are two critical stages of oocyte meiotic maturation. Here, we… read more here.
Keywords: cdh1; anaphase; transition; meiotic resumption ... See more keywords
Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007029
Abstract: Anaphase onset is an irreversible cell cycle transition that is triggered by the activation of the protease Separase. Separase cleaves the Mcd1 (also known as Scc1) subunit of Cohesin, a complex of proteins that physically… read more here.
Keywords: anaphase; separase; esp1; cohesin ... See more keywords
Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009592
Abstract: The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-dependent kinase to… read more here.
Keywords: bub1; anaphase; pp1; fin1 pp1 ... See more keywords
The Hybrid Incompatibility Genes Lhr and Hmr Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function
Sign Up to like & getrecommendations! Published in 2017 at "Genetics"
DOI: 10.1534/genetics.117.300390
Abstract: Crosses between Drosophila melanogaster females and Drosophila simulans males produce hybrid sons that die at the larval stage. This hybrid lethality is suppressed by loss-of-function mutations in the D. melanogaster Hybrid male rescue (Hmr) or… read more here.
Keywords: function; sister; anaphase; hmr lhr ... See more keywords
Separase and Roads to Disengage Sister Chromatids during Anaphase
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054604
Abstract: Receiving complete and undamaged genetic information is vital for the survival of daughter cells after chromosome segregation. The most critical steps in this process are accurate DNA replication during S phase and a faithful chromosome… read more here.
Keywords: spindle apparatus; chromosome segregation; anaphase; sister chromatids ... See more keywords