Dictamnine is an effective anti‐anaphylactoid compound acting via the MrgX2 receptor located on mast cells
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DOI: 10.1002/ptr.7007
Abstract: Anaphylactoid reactions are potentially fatal allergic diseases caused by mast cells (MCs), which release histamine and lipid mediators under certain stimuli. Therefore, there is an urgent need to develop new drug candidates to treat anaphylactoid… read more here.
Keywords: mrgx2 receptor; anaphylactoid reactions; mast cells; anti anaphylactoid ... See more keywords
Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs
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DOI: 10.1038/s41598-017-14224-z
Abstract: Anaphylactoid reactions are common clinical acute adverse drug reactions that can exacerbate a patient’s condition and produce effects that may become life-threatening. Therefore, it is important to establish a novel method to evaluate drugs for… read more here.
Keywords: anaphylactoid reactions; release index; lad2 cells; relative release ... See more keywords
Comment on “The changing face of paracetamol toxicity and new regimens for an old antidote acetylcysteine”
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DOI: 10.1111/bcp.14600
Abstract: Dear Editor, We have with interest read the recently published commentary by Isbister and Chiew in which current approaches for the treatment of paracetamol poisoning with N-acetylcysteine (NAC) were described. While we appreciate the authors'… read more here.
Keywords: anaphylactoid reactions; treatment; comment changing; time ... See more keywords