Initial Management of BRAF V600E-Variant Anaplastic Thyroid Cancer: The FAST Multidisciplinary Group Consensus Statement.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2024.2133
Abstract: Importance BRAF/MEK inhibitors revolutionized the treatment of BRAF V600E-variant anaplastic thyroid carcinoma (BRAFv-ATC), offering improved outcomes for patients with this previously incurable disease. Observations Anaplastic thyroid carcinoma (ATC) accounts for approximately half of thyroid cancer-related… read more here.
Keywords: consensus; cancer; treatment; braf ... See more keywords
Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer.
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DOI: 10.1002/1873-3468.70207
Abstract: Anaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy characterized by dedifferentiation and radioiodine refractoriness. We investigated whether EZH2-mediated H3K27me3 deposition represses thyroid differentiation genes (TDGs) in ATC cells. Online ChIP-seq analyses and CUT&RUN confirmed… read more here.
Keywords: iodide uptake; anaplastic thyroid; thyroid cancer; cell ... See more keywords
Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer
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DOI: 10.1002/advs.202204334
Abstract: Restoring sodium iodide symporter (NIS) expression and function remains a major challenge for radioiodine therapy in anaplastic thyroid cancer (ATC). For more efficient delivery of messenger RNA (mRNA) to manipulate protein expression, a lipid‐peptide‐mRNA (LPm)… read more here.
Keywords: mrna; peptide; thyroid cancer; lipid peptide ... See more keywords
Increased cytoplasmatic expression of cancer immune surveillance receptor CD1d in anaplastic thyroid carcinomas
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DOI: 10.1002/cam4.2573
Abstract: Anaplastic thyroid carcinomas are associated with rapid tumor growth, short survival time and without any promising therapy to improve the poor prognosis. In this study, expression of immunoregulative receptor CD1d and lymphocyte infiltration in different… read more here.
Keywords: receptor cd1d; thyroid carcinomas; anaplastic thyroid; expression ... See more keywords
Response to neoadjuvant paclitaxel predicts survival in anaplastic thyroid carcinoma
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DOI: 10.1002/cam4.5219
Abstract: The clinical utilities of paclitaxel in anaplastic thyroid carcinoma (ATC) have been reported. The current study investigated the outcomes in ATC patients treated by paclitaxel as neoadjuvant setting. Furthermore, the prognostic factor for overall survival… read more here.
Keywords: thyroid carcinoma; response paclitaxel; paclitaxel; response ... See more keywords
The American Thyroid Association (ATA) integrates molecular testing into its framework for managing patients with anaplastic thyroid carcinoma (ATC): Update on the 2021 ATA ATC guidelines
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22519
Abstract: The recently published 2021 guidelines for the management of patients with anaplastic thyroid cancer from the American Thyroid Association provide updated recommendations and guidance for the treatment of this rare but lethal thyroid cancer and… read more here.
Keywords: patients anaplastic; american thyroid; anaplastic thyroid; ata ... See more keywords
A unique case of anaplastic thyroid carcinoma comprising of two distinct patterns osteoclastic variant and squamous cell carcinoma in separate lobe imitating collision tumor: A case report
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25085
Abstract: Anaplastic thyroid carcinoma with two distinct morphologies in two lobes with no intermixing is very rare and not reported earlier. Furthermore, osteoclastic variant of anaplastic thyroid carcinoma as well as primary squamous cell carcinoma without… read more here.
Keywords: thyroid carcinoma; two distinct; case; anaplastic thyroid ... See more keywords
Integrated analysis of transcriptome data revealed MMP3 and MMP13 as critical genes in anaplastic thyroid cancer progression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28793
Abstract: To better understand the molecular mechanisms of anaplastic thyroid carcinoma (ATC), we aimed to identify the hub genes specifically involved in ATC by integrated bioinformatics analysis. In this study, using three Gene Expression Omnibus data… read more here.
Keywords: anaplastic thyroid; analysis; thyroid cancer; mmp3 mmp13 ... See more keywords
TMTP1‐Modified Small Extracellular Vesicles Target BRAF Mutation in Anaplastic Thyroid Cancer Reversing Vemurafenib Resistance With CRISPR/Cas9 Delivery
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DOI: 10.1002/jev2.70170
Abstract: ABSTRACT This study investigates a novel approach to overcome Vemurafenib resistance in BRAF‐mutant Anaplastic thyroid carcinoma (ATC) using CRISPR/Cas9 gene editing and TMTP1‐modified extracellular vesicles (TMTP1‐sgBRAF‐EVs). By knocking out the BRAF gene, the study elucidates… read more here.
Keywords: extracellular vesicles; anaplastic thyroid; delivery; tmtp1 modified ... See more keywords
Mutations in Anaplastic Thyroid Carcinoma: An Analysis of the Japanese National Genomic Database
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DOI: 10.1002/lio2.70110
Abstract: The purpose of this study is to investigate the genetic mutational status of anaplastic thyroid carcinoma (ATC) and its prognostic implications. read more here.
Keywords: carcinoma analysis; anaplastic thyroid; mutations anaplastic; thyroid carcinoma ... See more keywords
Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy‐lysosome mediated OCT4A degradation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7361
Abstract: Capsaicin (CAP) is a well‐known anti‐cancer agent. Recently, we reported capsaicin‐induced apoptosis in anaplastic thyroid cancer (ATC) cells. It is well accepted that the generation of cancer stem cells (CSCs) is responsible for the dedifferentiation… read more here.
Keywords: cap; degradation; anaplastic thyroid; capsaicin ... See more keywords