Ancestral reconstruction and correlation of the frequencies of the hemoglobin S allele and the Duffy blood group alleles in human populations
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Human Biology"
DOI: 10.1002/ajhb.23832
Abstract: Objectives: Malaria is an important selective force for human genetic adaptation due to the sustained, lethal impact it has had on populations worldwide. High frequencies of both hemoglobin S and the null allele FYBES of… read more here.
Keywords: duffy blood; human populations; ancestral reconstruction; correlation frequencies ... See more keywords
SubRecon: ancestral reconstruction of amino acid substitutions along a branch in a phylogeny
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty101
Abstract: Summary Existing ancestral sequence reconstruction techniques are ill‐suited to investigating substitutions on a single branch of interest. We present SubRecon, an implementation of a hybrid technique integrating joint and marginal reconstruction for protein sequence data.… read more here.
Keywords: reconstruction; reconstruction amino; along branch; ancestral reconstruction ... See more keywords
Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.11.480122
Abstract: Gene duplication is crucial to generating novel signaling pathways during evolution. However, it remains unclear how the redundant proteins produced by gene duplication ultimately acquire new interaction specificities to establish insulated paralogous signaling pathways. Here,… read more here.
Keywords: duplicated signaling; ancestral reconstruction; reconstruction duplicated; specificity ... See more keywords
Ancestral reconstruction of protein interaction networks
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007396
Abstract: The molecular and cellular basis of novelty is an active area of research in evolutionary biology. Until very recently, the vast majority of cellular phenomena were so difficult to sample that cross-species studies of biochemistry… read more here.
Keywords: protein interaction; interaction networks; biology; ancestral reconstruction ... See more keywords