Abstract A63: Characterizing the role of ancestry-specific variants of the Duffy Antigen Receptor for Chemokines (DARC) gene in the breast tumor microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.advbc17-a63
Abstract: Chemokines play an important role in cancer, as they direct infiltrating immune cells and mediate angiogenesis, tumor progression, and direct metastasis to distal sites. This work focuses on an atypical chemokine receptor, named the Duffy… read more here.
Keywords: breast tumor; receptor; gene; ancestry specific ... See more keywords
Ancestry-specific predisposing germline variants in cancer
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DOI: 10.1186/s13073-020-00744-3
Abstract: Background Distinct prevalence of inherited genetic predisposition may partially explain the difference of cancer risks across ancestries. Ancestry-specific analyses of germline genomes are required to inform cancer genetic risk and prognosis of diverse populations. Methods… read more here.
Keywords: variants cancer; predisposition; association; cancer ... See more keywords
Ancestry-specific gene expression profiles in TNBC tumors.
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DOI: 10.1200/jco.2020.38.15_suppl.1547
Abstract: 1547Background: Due to persistent disparities in breast cancer mortality, there has been a renewed focus on investigating tumor biology. Deeper exploration has exposed distinctions in tumor biology... read more here.
Keywords: expression profiles; gene expression; specific gene; profiles tnbc ... See more keywords
Identification of novel and rare variants associated with handgrip strength using whole genome sequence data from the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program
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DOI: 10.1371/journal.pone.0253611
Abstract: Handgrip strength is a widely used measure of muscle strength and a predictor of a range of morbidities including cardiovascular diseases and all-cause mortality. Previous genome-wide association studies of handgrip strength have focused on common… read more here.
Keywords: medicine; strength; whole genome; associated handgrip ... See more keywords