Synthesis of Enantioenriched Bromohydrins via Divergent Reactions of Racemic Intermediates from Anchimeric Oxygen Borrowing.
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DOI: 10.1021/jacs.8b06432
Abstract: We report a chiral phosphoric acid catalyzed bromocyclization/regiodivergent reaction of racemic intermediates sequence, which is enabled by anchimeric oxygen borrowing. Different types of alkenes are applicable, and both enantiomers of the bromohydrin products were obtained… read more here.
Keywords: racemic intermediates; synthesis enantioenriched; oxygen borrowing; anchimeric oxygen ... See more keywords