A Catch and Anchor Approach to Combat both Toxicity and Longevity of Botulinum Toxin A.
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DOI: 10.1021/acs.jmedchem.0c01006
Abstract: Botulinum neurotoxins have remarkable persistence (~weeks to months in cells), outlasting the small molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores - a zinc binding group and a Cys-reactive… read more here.
Keywords: anchor approach; approach combat; toxicity; catch anchor ... See more keywords