Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
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DOI: 10.1038/s41467-021-23609-8
Abstract: Despite recent success in computational design of structured cyclic peptides, de novo design of cyclic peptides that bind to any protein functional site remains difficult. To address this challenge, we develop a computational “anchor extension”… read more here.
Keywords: design cyclic; anchor extension; approach; cyclic peptides ... See more keywords