Independent effects of Src kinase and podoplanin on anchorage independent cell growth and migration
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23410
Abstract: The Src tyrosine kinase is a strong tumor promotor. Over a century of research has elucidated fundamental mechanisms that drive its oncogenic potential. Src phosphorylates effector proteins to promote hallmarks of tumor progression. For example,… read more here.
Keywords: cell; growth; kinase; src kinase ... See more keywords
Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the β-catenin/ID2 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Oncology"
DOI: 10.1007/s13402-019-00460-0
Abstract: Peroxiredoxin 4 (PRDX4) has been reported to play a dual role in the progression of hepatocellular carcinoma (HCC). As yet, however, the underlying molecular mechanism has not been fully elucidated. We examined the effects of… read more here.
Keywords: prdx4; hcc cells; anchorage independent; metastasis ... See more keywords
The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage‐independent growth in non‐small cell human lung cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.10.020
Abstract: ABSTRACT The capacity of cancer cells to resist detachment‐induced apoptosis, i.e. anoikis, as well as anchorage‐independent growth are crucial prerequisites for tumor metastasis. Therefore, agents interfering these properties may provide novel anti‐metastatic strategies. Sulforaphane (SFN),… read more here.
Keywords: anchorage independent; sfn; independent growth; cancer cells ... See more keywords
MiR-193b, downregulated in Ewing Sarcoma, targets the ErbB4 oncogene to inhibit anchorage-independent growth
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DOI: 10.1371/journal.pone.0178028
Abstract: Ewing Sarcoma is an aggressive, oncofusion-driven, malignant neoplasm of bone and soft tissue affecting predominantly children and young adults. Seeking to identify potential novel therapeutic targets/agents for this disease, our previous studies uncovered microRNAs regulated… read more here.
Keywords: anchorage independent; independent growth; ewing sarcoma; mir 193b ... See more keywords
ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature
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DOI: 10.3390/biom12081142
Abstract: Background: Epitranscriptomic mechanisms, such as A-to-I RNA editing mediated by ADAR deaminases, contribute to cancer heterogeneity and patients’ stratification. ADAR enzymes can change the sequence, structure, and expression of several RNAs, affecting cancer cell behavior.… read more here.
Keywords: decrease; cell; adar2 protein; gbm ... See more keywords
The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22020627
Abstract: Cancer is a global health concern, and the prognosis of patients with cancer is associated with metastasis. Multistep processes are involved in cancer metastasis. Accumulating evidence has shown that cancer cells acquire the capacity of… read more here.
Keywords: anchorage independent; anoikis; noncoding rnas; cancer ... See more keywords